J. Ferlay, H. Shin, F. Bray, D. Forman, C. Mathers et al., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008, International Journal of Cancer, vol.8, issue.19, pp.2893-2917, 2010.
DOI : 10.1002/ijc.25516

H. El-serag, Hepatocellular carcinoma, pp.1118-1127, 2011.

A. Forner, J. Llovet, and J. Bruix, Hepatocellular carcinoma, Lancet, vol.2012, issue.3799822, pp.1245-1255
URL : https://hal.archives-ouvertes.fr/hal-01134844

J. Nault, P. Bioulac-sage, and J. Zucman-rossi, Hepatocellular Benign Tumors???From Molecular Classification to Personalized Clinical Care, Gastroenterology, vol.144, issue.5, pp.888-902
DOI : 10.1053/j.gastro.2013.02.032

P. Bioulac-sage, S. Rebouissou, C. Thomas, J. Blanc, J. Saric et al., Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry, Hepatology, vol.25, issue.3, pp.740-748, 2007.
DOI : 10.1002/hep.21743

J. Zucman-rossi, E. Jeannot, J. Nhieu, J. Scoazec, C. Guettier et al., Genotype???phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC, Hepatology, vol.41, issue.3, pp.43515-524, 2006.
DOI : 10.1002/hep.21068

URL : https://hal.archives-ouvertes.fr/inserm-00130314

Y. Hoshida, S. Toffanin, A. Lachenmayer, A. Villanueva, B. Minguez et al., Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis, pp.35-51, 2010.

S. Boyault, D. Rickman, D. Reynies, A. Balabaud, C. Rebouissou et al., Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets, Hepatology, vol.12, issue.1, pp.42-52, 2007.
DOI : 10.1002/hep.21467

URL : https://hal.archives-ouvertes.fr/inserm-00130313

K. Berger, J. Cooper, N. Heaton, R. Yoon, T. Oakland et al., Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication, Proceedings of the National Academy of Sciences, vol.106, issue.18, pp.1067577-7582, 2009.
DOI : 10.1073/pnas.0902693106

J. Borawski, P. Troke, X. Puyang, V. Gibaja, S. Zhao et al., Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication, Journal of Virology, vol.83, issue.19, pp.8310058-10074, 2009.
DOI : 10.1128/JVI.02418-08

A. Tai, Y. Benita, L. Peng, S. Kim, N. Sakamoto et al., A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication, Cell Host & Microbe, vol.5, issue.3, pp.298-307, 2009.
DOI : 10.1016/j.chom.2009.02.001

M. Trotard, C. Lepere-douard, M. Regeard, C. Piquet-pellorce, D. Lavillette et al., Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening, The FASEB Journal, vol.23, issue.11
DOI : 10.1096/fj.09-131920

URL : https://hal.archives-ouvertes.fr/hal-00676358

F. Vaillancourt, L. Pilote, M. Cartier, J. Lippens, M. Liuzzi et al., Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication, Virology, vol.387, issue.1, pp.5-10, 2009.
DOI : 10.1016/j.virol.2009.02.039

S. Minogue and M. Waugh, The Phosphatidylinositol 4-Kinases: Don???t Call it a Comeback, Subcell Biochem, vol.58, pp.1-24, 2012.
DOI : 10.1007/978-94-007-3012-0_1

A. Blumental-perry, C. Haney, K. Weixel, S. Watkins, O. Weisz et al., Phosphatidylinositol 4-Phosphate Formation at ER Exit Sites Regulates ER Export, Developmental Cell, vol.11, issue.5, pp.671-682, 2006.
DOI : 10.1016/j.devcel.2006.09.001

URL : http://doi.org/10.1016/j.devcel.2006.09.001

H. Farhan, M. Weiss, K. Tani, R. Kaufman, and H. Hauri, Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load, The EMBO Journal, vol.115, issue.15, pp.2043-2054, 2008.
DOI : 10.1038/emboj.2008.136

A. Balla, Y. Kim, P. Varnai, Z. Szentpetery, Z. Knight et al., Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase III??, Molecular Biology of the Cell, vol.19, issue.2, pp.711-721, 2008.
DOI : 10.1091/mbc.E07-07-0713

D. Paolo, G. , D. Camilli, and P. , Phosphoinositides in cell regulation and membrane dynamics, Nature, vol.26, issue.7112, pp.651-657, 2006.
DOI : 10.1038/nature05185

M. Waugh, Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer, Cancer Letters, vol.325, issue.2, pp.125-131
DOI : 10.1016/j.canlet.2012.06.009

J. Nault, D. Reynies, A. Villanueva, A. Calderaro, J. Rebouissou et al., A Hepatocellular Carcinoma 5-Gene Score Associated with Survival of Patients Following Liver Resection, Gastroenterology, vol.2013, issue.1451, pp.176-187

P. Laurent-puig, P. Legoix, O. Bluteau, J. Belghiti, D. Franco et al., Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis, Gastroenterology, vol.120, issue.7, pp.1763-1773, 2001.
DOI : 10.1053/gast.2001.24798

P. Gripon, S. Rumin, S. Urban, L. Seyec, J. Glaise et al., Infection of a human hepatoma cell line by hepatitis B virus, Proc Natl Acad Sci, issue.24, pp.9915655-15660, 2002.

J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, T. Kato et al., Robust hepatitis C virus infection in vitro, Proceedings of the National Academy of Sciences, vol.102, issue.26, pp.1029294-9299, 2005.
DOI : 10.1073/pnas.0503596102

S. Rebouissou, S. Imbeaud, C. Balabaud, V. Boulanger, J. Bertrand-michel et al., HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation, J Biol Chem, issue.19, pp.28214437-14446, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00138278

D. Odom, N. Zizlsperger, D. Gordon, G. Bell, N. Rinaldi et al., Control of Pancreas and Liver Gene Expression by HNF Transcription Factors, Science, vol.303, issue.5662, pp.3031378-1381, 2004.
DOI : 10.1126/science.1089769

S. Reiss, I. Rebhan, P. Backes, I. Romero-brey, H. Erfle et al., Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment, Cell Host & Microbe, vol.9, issue.1, pp.32-45, 2011.
DOI : 10.1016/j.chom.2010.12.002

C. Guichard, G. Amaddeo, S. Imbeaud, Y. Ladeiro, L. Pelletier et al., Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma, Nature Genetics, vol.44, issue.6, pp.44694-698
DOI : 10.1006/meth.2001.1262

URL : https://hal.archives-ouvertes.fr/inserm-00719917

B. Sainz, . Jr, and F. Chisari, Production of Infectious Hepatitis C Virus by Well-Differentiated, Growth-Arrested Human Hepatoma-Derived Cells, Journal of Virology, vol.80, issue.20, pp.10253-10257, 2006.
DOI : 10.1128/JVI.01059-06

R. Parent, M. Marion, L. Furio, C. Trepo, and M. Petit, Origin and characterization of a human bipotent liver progenitor cell line???, Gastroenterology, vol.126, issue.4, pp.1147-1156, 2004.
DOI : 10.1053/j.gastro.2004.01.002

J. Lee, I. Chu, J. Heo, D. Calvisi, Z. Sun et al., Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling, Hepatology, vol.3, issue.3, pp.667-676, 2004.
DOI : 10.1002/hep.20375

J. Li, Y. Lu, J. Zhang, H. Kang, Z. Qin et al., PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation, Oncogene, issue.17, pp.292550-2559, 2010.

S. Ishikawa, H. Egami, T. Kurizaki, J. Akagi, Y. Tamori et al., Identification of genes related to invasion and metastasis in pancreatic cancer by cDNA representational difference analysis, J Exp Clin Cancer Res, vol.22, issue.2, pp.299-306, 2003.