Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer's and Semantic Dementia-Targeted Networks. - Archive ouverte HAL Access content directly
Journal Articles Neuron Year : 2014

Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer's and Semantic Dementia-Targeted Networks.

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Abstract

Alzheimer's disease (AD) and semantic dementia (SD) are both characterized by severe atrophy in the hippocampus, a brain region underlying episodic memory; paradoxically, episodic memory is relatively preserved in SD. Here, we used intrinsic connectivity analyses and showed that the brain networks differentially vulnerable to each disease converge to the hippocampus in the healthy brain. As neurodegeneration is thought to spread within preexisting networks, the common hippocampal atrophy in both diseases is likely due to its location at the crossroad between both vulnerable networks. Yet, we showed that in the normal brain, these networks harbor different functions, with episodic memory relying on the AD-vulnerable network only. Overall, disease-associated cognitive deficits seem to reflect the disruption of targeted networks more than atrophy in specific brain regions: in AD, over hippocampal atrophy, episodic memory deficits are likely due to disconnection within a memory-related network.
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Dates and versions

inserm-00931685 , version 1 (16-01-2014)

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Renaud La Joie, Brigitte Landeau, Audrey Perrotin, Alexandre Bejanin, Stéphanie Egret, et al.. Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer's and Semantic Dementia-Targeted Networks.: Brain networks, hippocampus and memory in dementia. Neuron, 2014, 81 (6), pp.1417-28. ⟨10.1016/j.neuron.2014.01.026⟩. ⟨inserm-00931685⟩
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