Understanding the role of domain-domain linkers in the spatial orientation of domains in multi-domain proteins.

Abstract : Inter-domain linkers (IDLs)' bridge flanking domains and support inter-domain communication in multi-domain proteins. Their sequence and conformational preferences enable them to carry out varied functions. They also provide sufficient flexibility to facilitate domain motions and, in conjunction with the interacting interfaces, they also regulate the inter-domain geometry (IDG). In spite of the basic intuitive understanding of the inter-domain orientations with respect to linker conformations and interfaces, we still do not entirely understand the precise relationship among the three. We show that IDG is evolutionarily well conserved and is constrained by the domain-domain interface interactions. The IDLs modulate the interactions by varying their lengths, conformations and local structure, thereby affecting the overall IDG. Results of our analysis provide guidelines in modelling of multi-domain proteins from the tertiary structures of constituent domain components.
Type de document :
Article dans une revue
Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2013, 31 (12), pp.1467-80. 〈10.1080/07391102.2012.743438〉
Liste complète des métadonnées

Littérature citée [70 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00926595
Contributeur : Alexandre G. De Brevern <>
Soumis le : jeudi 9 janvier 2014 - 19:36:25
Dernière modification le : lundi 23 juillet 2018 - 17:04:01
Document(s) archivé(s) le : samedi 8 avril 2017 - 13:49:15

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Ramachandra M Bhaskara, Alexandre De Brevern, Narayanaswamy Srinivasan. Understanding the role of domain-domain linkers in the spatial orientation of domains in multi-domain proteins.. Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2013, 31 (12), pp.1467-80. 〈10.1080/07391102.2012.743438〉. 〈inserm-00926595〉

Partager

Métriques

Consultations de la notice

178