Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID)

Aurélien Riquet 1, * Sébastien Chevalier 1 Julien Villaudy 2 Louis Gazzolo 2 Jean-Pierre Vartanian 3 Renaud Mahieux 1 Madeleine Duc-Dodon 2 Nathalie Bonnefoy 4
* Auteur correspondant
1 CIRI - Centre International de Recherche en Infectiologie
2 LBMC - Laboratoire de Biologie Moléculaire de la Cellule
3 Rétrovirologie moléculaire
4 IRCM - U896 Inserm - UM1 - Institut de recherche en cancérologie de Montpellier
Abstract : How T cells are transformed by HTLV-1 is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells. Tax has recently been shown to directly induce, in T cells, the expression of AID (Ishikawa C et al., Carcinogenesis, 2011), a cytidine deaminase whose physiologic expression is usually restricted to B cells, in which it initiates class-switch recombination and somatic hypermutations to reshape the primary antibody repertoire after antigen encounter. It is also well established that AID-mediated mutations outside of immunoglobulin gene locus are involved in the oncogenic transformation of B lymphocytes...
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Communication dans un congrès
16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses, Jun 2013, Montreal, Canada. Retrovirology, 11 (Suppl 1), pp.O45, 2014, 〈10.1186/1742-4690-11-S1-O45〉
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http://www.hal.inserm.fr/inserm-00924959
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Soumis le : mardi 7 janvier 2014 - 13:11:44
Dernière modification le : mardi 16 octobre 2018 - 01:19:22
Document(s) archivé(s) le : lundi 7 avril 2014 - 23:20:16

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ENS-LYON | VALDAURELLE | FNCLCC | PASTEUR | BS | UNIV-MONTPELLIER | UNIV-LYON1

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Aurélien Riquet, Sébastien Chevalier, Julien Villaudy, Louis Gazzolo, Jean-Pierre Vartanian, et al.. Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID). 16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses, Jun 2013, Montreal, Canada. Retrovirology, 11 (Suppl 1), pp.O45, 2014, 〈10.1186/1742-4690-11-S1-O45〉. 〈inserm-00924959〉

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