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Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID)

Abstract : How T cells are transformed by HTLV-1 is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells. Tax has recently been shown to directly induce, in T cells, the expression of AID (Ishikawa C et al., Carcinogenesis, 2011), a cytidine deaminase whose physiologic expression is usually restricted to B cells, in which it initiates class-switch recombination and somatic hypermutations to reshape the primary antibody repertoire after antigen encounter. It is also well established that AID-mediated mutations outside of immunoglobulin gene locus are involved in the oncogenic transformation of B lymphocytes...
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https://www.hal.inserm.fr/inserm-00924959
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Submitted on : Tuesday, January 7, 2014 - 1:11:44 PM
Last modification on : Monday, January 13, 2020 - 5:08:19 PM
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Aurélien Riquet, Sébastien Chevalier, Julien Villaudy, Louis Gazzolo, Jean-Pierre Vartanian, et al.. Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID). 16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses, Jun 2013, Montreal, Canada. pp.O45, ⟨10.1186/1742-4690-11-S1-O45⟩. ⟨inserm-00924959⟩

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