Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo.

Michel Desarménien 1 Carole Jourdan 1 Bertrand Toutain 2 Emilie Vessières 2 Sheriar Hormuzdi 3 Nathalie Guérineau 4, *
* Auteur correspondant
1 IGF - Institut de Génomique Fonctionnelle
2 Biologie Neurovasculaire et Mitochondriale Intégrée
3 Division of Neuroscience
4 Neurosecretion, Stress and Vascular Function
Biologie Neurovasculaire et Mitochondriale Intégrée
Abstract : Elucidating the mechanisms whereby neuroendocrine tissues coordinate their input and output signals to ensure appropriate hormone secretion is currently a topical issue. In particular, whether a direct communication mediated by gap junctions between neurosecretory cells contributes to hormone release in vivo still remains unknown. Here we address this issue using a microsurgical approach allowing combined monitoring of adrenal catecholamine secretion and splanchnic nerve stimulation in anaesthetised mice. Pharmacological blockade of adrenal gap junctions by the uncoupling agent carbenoxolone reduces nerve stimulation-evoked catecholamine release in control mice and to a larger extent in stressed mice. In parallel, the gap junction-coupled cell network is extended in stressed mice. Altogether, this argues for a significant contribution of adrenomedullary gap junctions to catecholamine secretion in vivo. As such, gap junctional signalling appears to be a substantial component for neuroendocrine function in the adrenal medulla, as it may represent an additional lever regulating hormone release.
Keywords : in vivo excitation-secretion coupling gap junction blocker adrenal catecholamine secretion cold stress Cx36-deficient mouse
Type de document :
Article dans une revue
Nature Communications, Nature Publishing Group, 2013, 4, pp.2938. 〈10.1038/ncomms3938〉
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http://www.hal.inserm.fr/inserm-00924268
Contributeur : Nathalie C. Guerineau <>
Soumis le : lundi 23 juin 2014 - 10:53:10
Dernière modification le : lundi 5 février 2018 - 15:00:10
Document(s) archivé(s) le : mardi 23 septembre 2014 - 10:41:47

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UNIV-ANGERS | BS | UNIV-MONTPELLIER

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Michel Desarménien, Carole Jourdan, Bertrand Toutain, Emilie Vessières, Sheriar Hormuzdi, et al.. Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo.. Nature Communications, Nature Publishing Group, 2013, 4, pp.2938. 〈10.1038/ncomms3938〉. 〈inserm-00924268〉

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