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Journal articles
Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo.
Abstract : Elucidating the mechanisms whereby neuroendocrine tissues coordinate their input and output signals to ensure appropriate hormone secretion is currently a topical issue. In particular, whether a direct communication mediated by gap junctions between neurosecretory cells contributes to hormone release in vivo still remains unknown. Here we address this issue using a microsurgical approach allowing combined monitoring of adrenal catecholamine secretion and splanchnic nerve stimulation in anaesthetised mice. Pharmacological blockade of adrenal gap junctions by the uncoupling agent carbenoxolone reduces nerve stimulation-evoked catecholamine release in control mice and to a larger extent in stressed mice. In parallel, the gap junction-coupled cell network is extended in stressed mice. Altogether, this argues for a significant contribution of adrenomedullary gap junctions to catecholamine secretion in vivo. As such, gap junctional signalling appears to be a substantial component for neuroendocrine function in the adrenal medulla, as it may represent an additional lever regulating hormone release.
https://www.hal.inserm.fr/inserm-00924268
Contributor : Nathalie C. Guerineau <>
Submitted on : Monday, June 23, 2014 - 10:53:10 AM
Last modification on : Thursday, September 17, 2020 - 4:24:03 PM
Long-term archiving on: : Tuesday, September 23, 2014 - 10:41:47 AM
Contributor : Nathalie C. Guerineau <>
Submitted on : Monday, June 23, 2014 - 10:53:10 AM
Last modification on : Thursday, September 17, 2020 - 4:24:03 PM
Long-term archiving on: : Tuesday, September 23, 2014 - 10:41:47 AM
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