Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.

Xavier Waltz; Marc Romana; Marie-Dominique Hardy-Dessources; Yann Lamarre; Lydia Divialle-Doumdo; Marie Petras; Vanessa Tarer; Régine Hierso; Kizzy-Clara Baltyde; Benoît Tressières; Marie-Laure Lalanne-Mistrih; Fréderic Maillard; Olivier Hue; Maryse Etienne-Julan; Philippe Connes

doi:10.1371/journal.pone.0077830

Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.

Xavier Waltz ^{1, 2, 3} Marc Romana ^{1, 3} Marie-Dominique Hardy-Dessources ^{3, 1} Yann Lamarre ^{1, 3} Lydia Divialle-Doumdo ⁴ Marie Petras ⁴ Vanessa Tarer ⁵ Régine Hierso ^{1, 3} Kizzy-Clara Baltyde ^{1, 3} Benoît Tressières ⁶ Marie-Laure Lalanne-Mistrih ^{1, 6} Fréderic Maillard ⁷ Olivier Hue ² Maryse Etienne-Julan ^{1, 4, 5} Philippe Connes ^{1, 2, 3, 8, *}

* Auteur correspondant

1 Protéines de la membrane érythrocytaire et homologues non-érythroides

2 ACTES - Adaptations au Climat Tropical, Exercice et Santé

3 Laboratory of Excellence GR-Ex "The red cell: from genesis to death"

4 Unité Transversale de la Drépanocytose

5 Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane

6 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane

7 Service de Pédiatrie

8 IUF - Institut Universitaire de France

Abstract : The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.

Type de document :

Article dans une revue

PLoS ONE, Public Library of Science, 2013, 8 (10), pp.e77830. 〈10.1371/journal.pone.0077830〉

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

Littérature citée [28 références] Voir Masquer Télécharger

http://www.hal.inserm.fr/inserm-00922110
Contributeur : Antoine Adenis <>
Soumis le : lundi 23 décembre 2013 - 17:56:52
Dernière modification le : vendredi 14 septembre 2018 - 08:15:58
Document(s) archivé(s) le : lundi 24 mars 2014 - 09:51:07

2013_Waltz_-_Hematological_and...

Fichiers éditeurs autorisés sur une archive ouverte

Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.

Fichier

Identifiants

Collections

Citation

Exporter

Métriques

377

264

Contact

Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.

Fichier

Identifiants

Collections

Citation

Exporter

Partager

Métriques

377

264

Contact