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Journal articles
Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.
Xavier Waltz
1, 2, 3
Marc Romana
1, 3
Marie-Dominique Hardy-Dessources
3, 1
Yann Lamarre
1, 3
Lydia Divialle-Doumdo
4
Marie Petras
4
Vanessa Tarer
5
Régine Hierso
1, 3
Kizzy-Clara Baltyde
1, 3
Benoît Tressières
6
Marie-Laure Lalanne-Mistrih
1, 6
Fréderic Maillard
7
Olivier Hue
2
Maryse Etienne-Julan
1, 4, 5
Philippe Connes
1, 2, 3, 8, *
*
Corresponding author
Xavier Waltz 1, 2, 3
Author
Marc Romana 1, 3
Author IdHAL : marc-romana ORCID : https://orcid.org/0000-0002-8715-9836
Marie-Dominique Hardy-Dessources 3, 1
Author
Yann Lamarre 1, 3
Author
Lydia Divialle-Doumdo 4
Author
Marie Petras 4
Author
Vanessa Tarer 5
Author
Régine Hierso 1, 3
Author
Kizzy-Clara Baltyde 1, 3
Author
Benoît Tressières 6
Author IdHAL : benoit-tressieres ORCID : https://orcid.org/0000-0002-9585-4281
Marie-Laure Lalanne-Mistrih 1, 6
Author
Fréderic Maillard 7
Author
Olivier Hue 2
Author Employer institution : Université des Antilles et de la Guyane
Maryse Etienne-Julan 1, 4, 5
Author
Philippe Connes 1, 2, 3, 8
Correspondent author IdHAL : philippe-connes ORCID : https://orcid.org/0000-0002-9232-0268
1
Protéines de la membrane érythrocytaire et homologues non-érythroides (INTS 6, Rue Alexandre Cabanel 75739 PARIS CEDEX 15 - France)
- UAG - Université des Antilles et de la Guyane (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
- INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- UR - Université de La Réunion (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U665 (101, rue de Tolbiac, 75013 Paris - France)
2
ACTES - Adaptations au Climat Tropical, Exercice et Santé (UFR STAPS Université des Antilles et de la Guyane - Fouillole - BP 250 - 97157 Pointe-à-Pitre cédex - France)
- UAG - Université des Antilles et de la Guyane : EA3596 (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
3
Laboratory of Excellence GR-Ex "The red cell: from genesis to death" (Paris - France)
- PRES Sorbonne Paris Cité (France)
4
Unité Transversale de la Drépanocytose (BP 465 - 97159 Pointe-à-Pitre Cedex - Guadeloupe)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- Hôpital Ricou (France)
5
Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane (Pointe-à-Pitre - Guadeloupe)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
6
CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane (Cayenne - French Guiana)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIE802 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- CHU de la Martinique [Fort de France] (CS 90632 – 97261 Fort de France Cedex Martinique - Martinique)
- Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
7
Service de Pédiatrie (Pointe-à-Pitre - Guadeloupe)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
8
IUF - Institut Universitaire de France (Maison des Universités 103 Boulevard Saint-Michel 75005 Paris - France)
- M.E.N.E.S.R. - Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (1 rue Descartes - 75231 Paris cedex 05 - France)
Abstract : The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six-minute walk test performance in children with sickle cell anemia. Hematological and hemorheological parameters, pulmonary function and the six-minute walk test performance were determined in 42 children with sickle cell anemia at steady state. The performance during the six-minute walk test was normalized for age, sex and height and expressed as percentage of the predicted six-minute walk distance. We showed that a high level of anemia, a low fetal hemoglobin expression and low red blood cell deformability were independent predictors of a low six-minute walk test performance. This study describes for the first time the impact of blood rheology in the six-minute walk test performance in children with sickle cell anemia.
Document type :
Journal articles
Complete list of metadata
https://www.hal.inserm.fr/inserm-00922110
Contributor : Antoine Adenis Connect in order to contact the contributor
Submitted on : Monday, December 23, 2013 - 5:56:52 PM
Last modification on : Wednesday, October 27, 2021 - 3:07:23 PM
Long-term archiving on: : Monday, March 24, 2014 - 9:51:07 AM
Contributor : Antoine Adenis Connect in order to contact the contributor
Submitted on : Monday, December 23, 2013 - 5:56:52 PM
Last modification on : Wednesday, October 27, 2021 - 3:07:23 PM
Long-term archiving on: : Monday, March 24, 2014 - 9:51:07 AM
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2013_Waltz_-_Hematological_and...
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Identifiers
- HAL Id : inserm-00922110, version 1
- DOI : 10.1371/journal.pone.0077830
- PUBMED : 24147086
Collections
AFRIQ | INSERM | UNIV-AG | ACTES | UNIV-PARIS7 | UNIV-PARIS
Citation
Xavier Waltz, Marc Romana, Marie-Dominique Hardy-Dessources, Yann Lamarre, Lydia Divialle-Doumdo, et al.. Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.. PLoS ONE, Public Library of Science, 2013, 8 (10), pp.e77830. ⟨10.1371/journal.pone.0077830⟩. ⟨inserm-00922110⟩
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