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Drawing a Waddington landscape to capture dynamic epigenetics.: Draw me a landscape

Floriane Nicol-Benoit 1 Pascale Le Goff 1 Denis Michel 2, *
* Corresponding author
2 Trec - Transcription, environnement et cancer
Irset - Institut de recherche en santé, environnement et travail
Abstract : Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided, is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.
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Floriane Nicol-Benoit, Pascale Le Goff, Denis Michel. Drawing a Waddington landscape to capture dynamic epigenetics.: Draw me a landscape. Biology of the Cell, Wiley, 2013, 105 (12), pp.576-84. ⟨10.1111/boc.201300029⟩. ⟨inserm-00920766⟩

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