Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.

Meriem Hasmim; Cécile Badoual; Philippe Vielh; Françoise Drusch; Virginie Marty; Agnès Laplanche; Mariana De Oliveira Diniz; Hélène Roussel; Eléonore De Guillebon; Stéphane Oudard; Stéphane Hans; Eric Tartour; Salem Chouaib

doi:10.1186/1471-2407-13-592

Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.

Meriem Hasmim ¹ Cécile Badoual ^{2, 3} Philippe Vielh ^{4, 5} Françoise Drusch ⁴ Virginie Marty ⁴ Agnès Laplanche ⁶ Mariana De Oliveira Diniz ² Hélène Roussel ^{2, 3} Eléonore De Guillebon ⁷ Stéphane Oudard ^{2, 7} Stéphane Hans ⁸ Eric Tartour ¹ Salem Chouaib ^{1, *}

* Auteur correspondant

1 U753 - Cytokines et Immunologie des Tumeurs Humaines

2 PARCC - U970 - Paris-Centre de Recherche Cardiovasculaire

3 Service d'anatomo-pathologie [CHU HEGP]

4 Laboratoire de recherche translationnelle

Direction de la recherche [Gustave Roussy]

5 Département de biologie et pathologie médicales [Gustave Roussy]

6 SBE - Service de biostatistique et d'épidémiologie

Direction de la recherche clinique [Gustave Roussy]

7 Service d'oncologie médicale [CHU HEGP]

8 Service d'oto-rhino-laryngologie et chirurgie cervico-faciale [CHU HEGP]

Abstract : BACKGROUND: Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in cancer has already been studied, the role of SCINDERIN presence remains to be established. In the present work, we investigated the prognosis value of EPHRIN-A1 and SCINDERIN expression in head and neck carcinomas. In addition, we monitored the HLA-class I expression by tumor cells and the presence of tumor-infiltrating CD8+ T cells to evaluate a putative correlation between these factors and the survival prognosis by themselves or related to EPHRIN-A1 and SCINDERIN expression. METHODS: Tumor tissue sections of 83 patients with head and neck cancer were assessed by immunohistochemistry for the expression of EPHRIN-A1, SCINDERIN, HLA class I molecules and the presence of CD8+ T cells. RESULTS: No significant prognosis value could be attributed to these factors independently, despite a tendency of association between EPHRIN-A1 and a worse clinical outcome. No prognostic value could be observed when CD8+ T cell tumor infiltration was analyzed combined with EPHRIN-A1, SCINDERIN or HLA class I expression. CONCLUSION: These results highlight that molecules involved in cancer cell resistance to cytotoxic T lymphocytes by themselves are not a sufficient criteria for prognosis determination in cancer patients. Other intrinsic or tumor microenvironmental features should be considered in prognostic evaluation.

Type de document :

Article dans une revue

BMC Cancer, BioMed Central, 2013, 13 (1), pp.592. 〈10.1186/1471-2407-13-592〉

Domaine :

Sciences du Vivant [q-bio] / Cancer

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Soumis le : mercredi 18 décembre 2013 - 21:01:44
Dernière modification le : mercredi 29 août 2018 - 01:10:24
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Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.

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Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.

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