Skip to Main content Skip to Navigation
Journal articles

Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes.

Abstract : Contractile dysfunction and subsequent development of cardiomyopathies are well known limiting factors in the treatment of cancer with doxorubicin and have been linked to mitochondrial dysfunction. Here, using adult isolated paced cardiomyocytes, we have demonstrated that ligands of translocator protein (TSPO) 4'-chlorodiazepam and TRO40303 prevented the doxorubicin-induced alterations in contractility and improved cardiomyocyte viability. This cardioprotective effect was closely associated with both a potent reduction in reactive oxygen species production and inhibition of mitochondrial permeability transition pore opening. Thus, preventive administration of TSPO ligands may represent a novel pharmacological strategy to protect the heart during doxorubicin treatment.
Document type :
Journal articles
Complete list of metadatas

Cited literature [5 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00920557
Contributor : Georges Guellaen <>
Submitted on : Wednesday, December 18, 2013 - 4:59:27 PM
Last modification on : Friday, October 4, 2019 - 1:37:52 AM
Long-term archiving on: : Wednesday, March 19, 2014 - 5:52:38 AM

Files

article_mitochondrion_pour_dA_...
Files produced by the author(s)

Identifiers

Collections

Citation

Alexandra d'Anglemont de Tassigny, Rana Assaly, Sophie Schaller, Rebecca Pruss, Alain Berdeaux, et al.. Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes.. Mitochondrion, Elsevier, 2013, 13 (6), pp.688-97. ⟨10.1016/j.mito.2013.10.001⟩. ⟨inserm-00920557⟩

Share

Metrics

Record views

484

Files downloads

1129