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Journal articles
Mitochondrial translocator protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated cardiomyocytes.
Abstract : Contractile dysfunction and subsequent development of cardiomyopathies are well known limiting factors in the treatment of cancer with doxorubicin and have been linked to mitochondrial dysfunction. Here, using adult isolated paced cardiomyocytes, we have demonstrated that ligands of translocator protein (TSPO) 4'-chlorodiazepam and TRO40303 prevented the doxorubicin-induced alterations in contractility and improved cardiomyocyte viability. This cardioprotective effect was closely associated with both a potent reduction in reactive oxygen species production and inhibition of mitochondrial permeability transition pore opening. Thus, preventive administration of TSPO ligands may represent a novel pharmacological strategy to protect the heart during doxorubicin treatment.
Cited literature [5 references]
https://www.hal.inserm.fr/inserm-00920557
Contributor : Georges Guellaen Connect in order to contact the contributor
Submitted on : Wednesday, December 18, 2013 - 4:59:27 PM
Last modification on : Tuesday, October 19, 2021 - 4:09:21 PM
Long-term archiving on: : Wednesday, March 19, 2014 - 5:52:38 AM
Contributor : Georges Guellaen Connect in order to contact the contributor
Submitted on : Wednesday, December 18, 2013 - 4:59:27 PM
Last modification on : Tuesday, October 19, 2021 - 4:09:21 PM
Long-term archiving on: : Wednesday, March 19, 2014 - 5:52:38 AM
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