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Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.

Rebecca Ritte 1 Kaja Tikk 1 Annekatrin Lukanova 1 Anne Tjønneland 2 Anja Olsen 2 Kim Overvad 3 Laure Dossus 4 Agnès Fournier 4 Françoise Clavel-Chapelon 4 Verena Grote 1 Heiner Boeing 5 Krasimira Aleksandrova 5 Antonia Trichopoulou 6, 7 Pagona Lagiou 6, 8, 9 Dimitrios Trichopoulos 8, 9 Domenico Palli 10 Franco Berrino 11 Amalia Mattiello 12 Rosario Tumino 13 Carlotta Sacerdote 14, 15 José Ramón Quirós 16 Genevieve Buckland 17 Esther Molina-Montes 18, 19 María-Dolores Chirlaque 19, 20 Eva Ardanaz 19, 21 Pilar Amiano 19, 22 Bas H. Bueno-De-Mesquita 23, 24, 25 Carla van Gils 26 Petra Peeters 26, 27 Nick Wareham 28 Kay-Tee Khaw 29 Timothy Key 30 Ruth Travis 30 Elisabete Weiderpass 31, 32, 33 Vanessa Dumeaux 31, 34 Eliv Lund 31 Malin Sund 35 Anne Andersson 36 Isabelle Romieu 37 Sabina Rinaldi 38 Paulo Vineis 15, 39 Melissa Merritt 39 Elio Riboli 39 Rudolf Kaaks 1, * 
* Corresponding author
Abstract : INTRODUCTION: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. METHODS: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors. RESULTS: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (>=35 vs. <=19 years HR: 1.47 [95%CI 1.15-1.88] ptrend < 0.001 for ER+PR+ tumors; >=35 vs. <=19 years HR: 0.93 [95%CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; Phet = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk. CONCLUSION: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.
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Submitted on : Wednesday, December 18, 2013 - 12:11:34 PM
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Rebecca Ritte, Kaja Tikk, Annekatrin Lukanova, Anne Tjønneland, Anja Olsen, et al.. Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.. BMC Cancer, BioMed Central, 2013, 13 (1), pp.584. ⟨10.1186/1471-2407-13-584⟩. ⟨inserm-00920375⟩



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