Skip to Main content Skip to Navigation
Journal articles

Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.

Abstract : Hepatitis E virus (HEV) has been identified as a cause of chronic viral hepatitis in immunocompromised patients. Some glomerular diseases were found to be associated with this infection. We report the first case, to our knowledge, of a kidney transplant recipient who developed an HEV infection and de novo membranous nephropathy (MN) concomitantly. The patient displayed a hepatic cytolysis first and a nephrotic syndrome occurred 3 months later. HEV infection was diagnosed upon positive polymerase chain reaction on plasma and stool samples, and renal allograft biopsy revealed de novo MN. Typical causes of MN were definitively excluded. A 3-month course of ribavirin monotherapy allowed the patient to mount a sustained viral response that was rapidly followed by complete remission of the nephrotic syndrome. The chronology of the onset and remission of both diseases is highly suggestive of a causal relationship between hepatitis E and MN.
Document type :
Journal articles
Complete list of metadatas

Cited literature [19 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00919073
Contributor : Pierre Ronco <>
Submitted on : Monday, December 16, 2013 - 12:00:01 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
Long-term archiving on: : Saturday, April 8, 2017 - 6:44:10 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Benjamin Taton, Karine Moreau, Sébastien Lepreux, Thomas Bachelet, Pascale Trimoulet, et al.. Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.. Transplant Infectious Disease, Wiley, 2013, 15 (6), pp.E211-5. ⟨10.1111/tid.12143⟩. ⟨inserm-00919073⟩

Share

Metrics

Record views

319