Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.

Benjamin Taton; Karine Moreau; Sébastien Lepreux; Thomas Bachelet; Pascale Trimoulet; Victor De Ledinghen; Antoine Pommereau; Pierre Ronco; Nassim Kamar; Pierre Merville; Lionel Couzi

doi:10.1111/tid.12143

Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.

Benjamin Taton ¹ Karine Moreau ¹ Sébastien Lepreux ¹ Thomas Bachelet ¹ Pascale Trimoulet ¹ Victor De Ledinghen ¹ Antoine Pommereau ² Pierre Ronco ³ Nassim Kamar ^{4, 5, 6} Pierre Merville ^{1, 7} Lionel Couzi ^{1, *}

* Auteur correspondant

1 CHU Bordeaux [Bordeaux]

2 Centre de traitement des maladies rénales

3 Remodelage et Reparation du Tissu Renal

4 UPS - Université Toulouse III - Paul Sabatier

5 CPTP - Centre de Physiopathologie de Toulouse Purpan

6 Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation

7 Service de Néphrologie-transplantation-dialyse [Bordeaux]

Abstract : Hepatitis E virus (HEV) has been identified as a cause of chronic viral hepatitis in immunocompromised patients. Some glomerular diseases were found to be associated with this infection. We report the first case, to our knowledge, of a kidney transplant recipient who developed an HEV infection and de novo membranous nephropathy (MN) concomitantly. The patient displayed a hepatic cytolysis first and a nephrotic syndrome occurred 3 months later. HEV infection was diagnosed upon positive polymerase chain reaction on plasma and stool samples, and renal allograft biopsy revealed de novo MN. Typical causes of MN were definitively excluded. A 3-month course of ribavirin monotherapy allowed the patient to mount a sustained viral response that was rapidly followed by complete remission of the nephrotic syndrome. The chronology of the onset and remission of both diseases is highly suggestive of a causal relationship between hepatitis E and MN.

Keywords : membranous nephropathy hepatitis E virus kidney transplantation ribavirin

Type de document :

Article dans une revue

Transplant Infectious Disease, Wiley, 2013, 15 (6), pp.E211-5. 〈10.1111/tid.12143〉

Domaine :

Sciences du Vivant [q-bio] / Biochimie, Biologie Moléculaire / Génomique, Transcriptomique et Protéomique [q-bio.GN]

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http://www.hal.inserm.fr/inserm-00919073
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Soumis le : lundi 16 décembre 2013 - 12:00:01
Dernière modification le : mercredi 12 septembre 2018 - 17:32:03
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Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.

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Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation.

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