[Anti-CD 10 maternal-fetal allo-immunisation].

Abstract : Maternal-fetal alloimmunisation with antenatal glomerulopathies (FMAIG) is a recently described allo-immune disorder that results from the production of maternal antibodies which cross the placenta, bind to fetal glomerular podocytes and thereby cause renal dysfunction. The pathogenic antibodies are directed against CD10/neutral endopeptidase (NEP). The infant's mother is apparently healthy but is genetically NEP-deficient, and thus becomes immunized against CD10/NEP expressed by placental cells during her first pregnancy. This disease, that we have now diagnosed in five families, is the first described organ-specific disorder due to maternal-fetal allo-immunisation. Because future pregnancies in CD10/NEP-immunized mothers are at high risk for the fetus, antigen-driven therapies aimed at eliminating pathogenic antibodies are urgently needed. This will require identification of the pathogenic epitopes born by the antigen.
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Article dans une revue
Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2012, 196 (8), pp.1613-22; discussion 1622-3
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Contributeur : Pierre Ronco <>
Soumis le : lundi 16 décembre 2013 - 11:08:48
Dernière modification le : mercredi 21 mars 2018 - 18:57:25
Document(s) archivé(s) le : mardi 18 mars 2014 - 15:45:41

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  • HAL Id : inserm-00919012, version 1
  • PUBMED : 24313016

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Pierre Ronco, Hanna Debiec. [Anti-CD 10 maternal-fetal allo-immunisation].. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2012, 196 (8), pp.1613-22; discussion 1622-3. 〈inserm-00919012〉

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