Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing.

Abstract : We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
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Submitted on : Wednesday, December 11, 2013 - 3:02:43 PM
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Jérémie Cohen, Robert Cohen, Philippe Bidet, Corinne Levy, Patrice Deberdt, et al.. Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing.. J Pediatr, 2013, 162 (6), pp.1282-4, 1284.e1. ⟨10.1016/j.jpeds.2013.01.050⟩. ⟨inserm-00917225⟩

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