Skip to Main content Skip to Navigation
Journal articles

[The Warburg effect: from theory to therapeutic applications in cancer].

Abstract : Cancer cell metabolism described by Otto Warburg in the thirties became a cancer specific hallmark, also called "Warburg effect". Cancer cells use essentially glucose as fuel, through glycolysis, in order to meet their energy and biomass needs to insure their cell proliferation. Recent advances describe Warburg effect regulation by oncogenes and tumor suppressor genes. Moreover, mutations in some glycolysis enzymes are found in various cancers, highlighting the role of cell metabolism in cancer. In this review, we describe the mechanisms responsible for the Warburg effect at the molecular and cellular level, the role of cell signalling along with the implication of different transcription factors. As a cause or a consequence of tumorigenesis, the Warburg effect is now considered as a promising therapeutic target in the fight against cancer.
Document type :
Journal articles
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00916778
Contributor : Yves Le Ster <>
Submitted on : Tuesday, December 10, 2013 - 4:49:36 PM
Last modification on : Tuesday, January 14, 2020 - 12:04:06 PM
Long-term archiving on: : Friday, March 14, 2014 - 10:10:23 AM

Files

Revue_Warburg_MedSciences_reI_...
Files produced by the author(s)

Identifiers

Collections

Citation

Julie Razungles, Vincent Cavaillès, Stéphan Jalaguier, Catherine Teyssier. [The Warburg effect: from theory to therapeutic applications in cancer].. médecine/sciences, EDP Sciences, 2013, 29 (11), pp.1026-33. ⟨10.1051/medsci/20132911020⟩. ⟨inserm-00916778⟩

Share

Metrics

Record views

458

Files downloads

5333