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The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease.

Abstract : INTRODUCTION: Epidemiological studies indicate that significant decreases in the incidence of Alzheimer's disease (AD) may be obtained by targeting multiple middle-age risk factors. However, as dementia is unlikely to be diagnosed for decades, short-term outcome measures are required. AD biomarker changes precede clinical symptoms by many years, but their sensitivity to mid-life change remains unknown. METHODS AND ANALYSIS: PREVENT is a prospective cohort study examining biomarker status at mid-life in at least 150 individuals genetically at high, medium or low risk of late-onset AD. Participants are children of individuals with or without a diagnosed AD allocated to high, medium and low-risk groups according to parental clinical status and ApoE genotype. The biomarkers examined over 2 years are plasma and CSF Aβ42 amyloid, Tau and pTau, proinflammatory cytokines, acute-phase proteins, medial temporal-lobe atrophy, white matter lesion volume, cognitive performance related to transentorhinal and hippocampal functioning and hypothalamic-pituitary-adrenal and sympathetic axes regulation. ETHICS AND DISSEMINATION: Detected pathologies are communicated to the participant's general practitioner with their permission. Risk status by genotype would not be revealed. The results of the study would be published in peer-reviewed journals and validated biomarkers used to construct a randomised controlled intervention study.
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Submitted on : Thursday, December 5, 2013 - 12:31:58 PM
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Craig W. Ritchie, Karen Ritchie. The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease.. BMJ Open, BMJ Publishing Group, 2012, 2 (6), epub ahead of print. ⟨10.1136/bmjopen-2012-001893⟩. ⟨inserm-00914373⟩



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