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Attention orienting dysfunction with preserved automatic auditory change detection in migraine.

Abstract : OBJECTIVE:To investigate automatic event-related potentials (ERPs) to an auditory change in migraine patients.METHODS:Auditory ERPs were recorded in 22 female patients suffering from menstrually-related migraine and in 20 age-matched control subjects, in three sessions: in the middle of the menstrual cycle, before and during menses. In each session, 200 trains of tone-bursts each including two duration deviants were presented in a passive listening condition.RESULTS:In all sessions, duration deviance elicited a mismatch negativity (MMN) showing no difference between the two groups. However, migraine patients showed an increased N1 orienting component to all incoming stimuli and a prolonged N2b to deviance. They also presented a different modulation of P3a amplitude along the menstrual cycle, which tended to normalise during migraine attacks. None of the studied ERP components showed a default of habituation.CONCLUSIONS:This passive paradigm highlighted increased automatic attention orienting to auditory changes but normal auditory sensory processing in migraineurs.SIGNIFICANCE:Our observations suggest normal auditory processing up to attention triggering but enhanced activation of attention-related frontal networks in migraineurs.
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Contributor : Dominique Morlet Connect in order to contact the contributor
Submitted on : Thursday, December 5, 2013 - 12:19:45 PM
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Dominique Morlet, Geneviève Demarquay, Frédérique Brudon, Catherine Fischer, Anne Caclin. Attention orienting dysfunction with preserved automatic auditory change detection in migraine.. Clinical Neurophysiology, Elsevier, 2014, pp.500-11. ⟨10.1016/j.clinph.2013.05.032⟩. ⟨inserm-00914357⟩



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