Skip to Main content Skip to Navigation
Journal articles

Primary prophylaxis of disseminated histoplasmosis in HIV patients in French Guiana: arguments for cost effectiveness.

Abstract : Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana. Cohort data were used to determine whether primary prophylaxis with 100 mg itraconazole for patients with CD4 counts < 150/mm(3) was cost-effective with different scenarios. For a scenario where 12% of patients died, 60% were aware of their human immunodeficiency virus (HIV) infection and adherence was only 50%, primary prophylaxis would prevent 1 death and 9 cases of histoplasmosis for a cost of 36,792 Euros per averted death, 1,533 per life-year saved, 4,415 Euros per averted case, when only counting the costs of itraconazole prophylaxis. Taking into account the total costs of hospitalization showed that primary prophylaxis would allow a savings of 185,178 Euros per year. Even in a scenario of low adherence, primary prophylaxis would be cost-effective in French Guiana, and presumably in the rest of the Guianas and the Amazon.
Document type :
Journal articles
Complete list of metadatas

Cited literature [3 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00913886
Contributor : Antoine Adenis <>
Submitted on : Friday, October 3, 2014 - 10:51:45 AM
Last modification on : Saturday, December 14, 2019 - 1:20:02 PM
Long-term archiving on: : Sunday, January 4, 2015 - 10:12:23 AM

Files

2013_Nacher_-_Primary_prophyla...
Files produced by the author(s)

Identifiers

Collections

Citation

Mathieu Nacher, Antoine Adenis, Celia Basurko, Vincent Vantilcke, Denis Blanchet, et al.. Primary prophylaxis of disseminated histoplasmosis in HIV patients in French Guiana: arguments for cost effectiveness.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 89 (6), pp.1195-8. ⟨10.4269/ajtmh.13-0082⟩. ⟨inserm-00913886⟩

Share

Metrics

Record views

832

Files downloads

424