Towards an Atrio-Ventricular Delay optimization assessed by a computer model for Cardiac Resynchronization Therapy

David Ojeda 1 Virginie Le Rolle 1, * Kevin Tse Ve Koon 1 Christophe Thebault 1, 2 Erwan Donal 1 Alfredo Hernandez 1, *
* Auteur correspondant
1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Service de chirurgie thoracique cardiaque et vasculaire [Rennes]
Abstract : In this paper, lumped-parameter models of the cardiovascular system, the cardiac electrical conduction system and a pacemaker are coupled to generate mitral flow profiles for different atrio-ventricular delay (AVD) configurations, in the context of cardiac resynchronization therapy (CRT). First, we perform a local sensitivity analysis of left ventricular and left atrial parameters on mitral flow characteristics, namely E and A wave amplitude, mitral flow duration, and mitral flow time integral. Additionally, a global sensitivity analysis over all model parameters is presented to screen for the most relevant parameters that affect the same mitral flow characteristics. Results provide insight on the influence of left ventricle and atrium influence on mitral flow profiles. This information will be useful for future parameter estimation of the model that could reproduce the mitral flow profiles and cardiovascular hemodynamics of patients undergoing AVD optimization during CRT.
Keywords : Heart Failure Cardiac Resynchronization Therapy Sensitivity Analysis Modeling and Simulation
Type de document :
Communication dans un congrès
Jorge Brieva; Boris Escalante-Ramírez. IX International Seminar on Medical Information Processing and Analysis, Nov 2013, Mexico City, Mexico. SPIE, 8922, pp.892207, 2013, 〈10.1117/12.2041977〉
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Dernière modification le : vendredi 15 juin 2018 - 11:34:02
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David Ojeda, Virginie Le Rolle, Kevin Tse Ve Koon, Christophe Thebault, Erwan Donal, et al.. Towards an Atrio-Ventricular Delay optimization assessed by a computer model for Cardiac Resynchronization Therapy. Jorge Brieva; Boris Escalante-Ramírez. IX International Seminar on Medical Information Processing and Analysis, Nov 2013, Mexico City, Mexico. SPIE, 8922, pp.892207, 2013, 〈10.1117/12.2041977〉. 〈inserm-00912860〉

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