The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder

Cecilia Nauczyciel 1 Suzanne Robic 2 Thibaut Dondaine 3 Marc Verin 3 Gabriel Robert 1, 3 Dominique Drapier 1, 3 Florian Naudet 1, 3 Bruno Millet 1, 3, *
* Auteur correspondant
1 Service de Psychiatrie de l'adulte [Rennes]
2 CRNL - Centre de recherche en neurosciences de Lyon
3 Comportement et noyaux gris centraux [Rennes]
Abstract : Objective
This review aimed to investigate the therapeutic potential of Deep Brain Stimulation (DBS) for treating resistant Major Depressive Disorder (MDD). We explored the role of Nucleus accumbens (Nac) as a target for treatment.
Method
We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD.
Results
As a central relay-structure, the Nac seems to play a central role in MDD symptomatology. We investigated its role as a primary target for DBS in depressed patients. Anatomically the Nac is at the centre of the interactions between dopaminergic, serotoninergic and glutamatergic systems. Functionally, the Nac is involved in both normal and abnormal reward processes and in anhedonia and loss of motivation. Due to its central location between the emotional system, the cognitive system and motor control system, the Nac seems to have a central role in mood and feeling regulation.
Conclusion
According to encouraging recent studies, DBS seems to be a promising technique in resistant MDD treatment.
Mots-clés : Major depressive disorder Deep brain stimulation Dopamine Nucleus accumbens
Type de document :
Article dans une revue
Journal of Molecular Psychiatry, BioMed Central, 2013, 1 (1), pp.17. 〈10.1186/2049-9256-1-17〉
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Cecilia Nauczyciel, Suzanne Robic, Thibaut Dondaine, Marc Verin, Gabriel Robert, et al.. The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder. Journal of Molecular Psychiatry, BioMed Central, 2013, 1 (1), pp.17. 〈10.1186/2049-9256-1-17〉. 〈inserm-00911738〉

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