Kinetic analysis of [11C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A.

Paolo Zanotti-Fregonara 1, * Claire Leroy 2 Dimitri Roumenov 2 Christian Trichard 3 Jean-Luc Martinot 3 Michel Bottlaender 2, 3
* Auteur correspondant
1 INCIA - Institut de Neurosciences cognitives et intégratives d'Aquitaine
2 I2BM - Institut d'Imagerie BioMédicale
3 U1000 - Neuroimagerie en psychiatrie
Abstract : BACKGROUND: [11C]Befloxatone measures the density of the enzyme monoamine oxidase A (MAO-A) in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and psychiatric illnesses. This study sought to estimate the distribution volume (VT) values of [11C]befloxatone in humans using an arterial input function. METHODS: Seven healthy volunteers were imaged with positron emission tomography (PET) after [11C]befloxatone injection. Kinetic analysis was performed using an arterial input function in association with compartmental modeling and with the Logan plot, multilinear analysis (MA1), and standard spectral analysis (SA) at both the regional and voxel level. Arterialized venous samples were drawn as an alternative and less invasive input function. RESULTS: An unconstrained two-compartment model reliably quantified VT values in large brain regions. A constrained model did not significantly improve VT identifiability. Similar VT results were obtained using SA; however, the Logan plot and MA1 slightly underestimated VT values (about -10 %). At the voxel level, SA showed a very small bias (+2 %) compared to compartmental modeling, Logan severely underestimated VT values, and voxel-wise images obtained with MA1 were too noisy to be reliably quantified. Arterialized venous blood samples did not provide a satisfactory alternative input function as the Logan-VT regional values were not comparable to those obtained with arterial sampling in all subjects. CONCLUSIONS: Binding of [11C]befloxatone to MAO-A can be quantified using an arterial input function and a two-compartment model or, in parametric images, with SA.
Keywords : [11C]Befloxatone Monoamine oxidase A PET Spectral analysis
Type de document :
Article dans une revue
EJNMMI Research, BioMed Central, 2013, 3 (1), pp.78. 〈10.1186/2191-219X-3-78〉
Liste complète des métadonnées

Littérature citée [33 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00911737
Contributeur : Ed. Bmc <>
Soumis le : vendredi 29 novembre 2013 - 17:26:29
Dernière modification le : mardi 8 mai 2018 - 08:36:01
Document(s) archivé(s) le : lundi 3 mars 2014 - 20:30:20

Fichiers

2191-219X-3-78.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

CEA | UNIV-PARIS5 | USPC | CEA-DRF

Citation

Paolo Zanotti-Fregonara, Claire Leroy, Dimitri Roumenov, Christian Trichard, Jean-Luc Martinot, et al.. Kinetic analysis of [11C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A.. EJNMMI Research, BioMed Central, 2013, 3 (1), pp.78. 〈10.1186/2191-219X-3-78〉. 〈inserm-00911737〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

334

Téléchargements de fichiers

271

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD