Skip to Main content Skip to Navigation
Journal articles

Kinetic analysis of [11C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A.

Abstract : BACKGROUND: [11C]Befloxatone measures the density of the enzyme monoamine oxidase A (MAO-A) in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and psychiatric illnesses. This study sought to estimate the distribution volume (VT) values of [11C]befloxatone in humans using an arterial input function. METHODS: Seven healthy volunteers were imaged with positron emission tomography (PET) after [11C]befloxatone injection. Kinetic analysis was performed using an arterial input function in association with compartmental modeling and with the Logan plot, multilinear analysis (MA1), and standard spectral analysis (SA) at both the regional and voxel level. Arterialized venous samples were drawn as an alternative and less invasive input function. RESULTS: An unconstrained two-compartment model reliably quantified VT values in large brain regions. A constrained model did not significantly improve VT identifiability. Similar VT results were obtained using SA; however, the Logan plot and MA1 slightly underestimated VT values (about -10 %). At the voxel level, SA showed a very small bias (+2 %) compared to compartmental modeling, Logan severely underestimated VT values, and voxel-wise images obtained with MA1 were too noisy to be reliably quantified. Arterialized venous blood samples did not provide a satisfactory alternative input function as the Logan-VT regional values were not comparable to those obtained with arterial sampling in all subjects. CONCLUSIONS: Binding of [11C]befloxatone to MAO-A can be quantified using an arterial input function and a two-compartment model or, in parametric images, with SA.
Document type :
Journal articles
Complete list of metadatas

Cited literature [33 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00911737
Contributor : Ed. Bmc <>
Submitted on : Friday, November 29, 2013 - 5:26:29 PM
Last modification on : Wednesday, October 14, 2020 - 3:40:23 AM
Long-term archiving on: : Monday, March 3, 2014 - 8:30:20 PM

Files

2191-219X-3-78.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Paolo Zanotti-Fregonara, Claire Leroy, Dimitri Roumenov, Christian Trichard, Jean-Luc Martinot, et al.. Kinetic analysis of [11C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A.. EJNMMI Research, SpringerOpen, 2013, 3 (1), pp.78. ⟨10.1186/2191-219X-3-78⟩. ⟨inserm-00911737⟩

Share

Metrics

Record views

667

Files downloads

1177