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The primate working memory networks.

Abstract : Working memory has long been associated with the prefrontal cortex, since damage to this brain area can critically impair the ability to maintain and update mnemonic information. Anatomical and physiological evidence suggests, however, that the prefrontal cortex is part of a broader network of interconnected brain areas involved in working memory. These include the parietal and temporal association areas of the cerebral cortex, cingulate and limbic areas, and subcortical structures such as the mediodorsal thalamus and the basal ganglia. Neurophysiological studies in primates confirm the involvement of areas beyond the frontal lobe and illustrate that working memory involves parallel, distributed neuronal networks. In this article, we review the current understanding of the anatomical organization of networks mediating working memory and the neural correlates of memory manifested in each of their nodes. The neural mechanisms of memory maintenance and the integrative role of the prefrontal cortex are also discussed.
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Contributor : Emmanuel Procyk Connect in order to contact the contributor
Submitted on : Wednesday, November 20, 2013 - 12:33:50 PM
Last modification on : Tuesday, October 19, 2021 - 11:00:03 AM
Long-term archiving on: : Friday, February 21, 2014 - 4:27:41 AM


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  • HAL Id : inserm-00906775, version 1
  • PUBMED : 15849890



Christos Constantinidis, Emmanuel Procyk. The primate working memory networks.. Cognitive, Affective, and Behavioral Neuroscience, Springer Verlag, 2004, 4 (4), pp.444-65. ⟨inserm-00906775⟩



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