COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.

Perminder Sachdev 1, 2, * Darren Lipnicki 1 Nicole Kochan 1 John Crawford 1 Kenneth Rockwood 3 Shifu Xiao 4 Juan Li 5 Xia Li 4 Carol Brayne 6 Fiona Matthews 7 Blossom Stephan 8 Richard Lipton 9, 10 Mindy Katz 10 Karen Ritchie 11, 12 Isabelle Carrière 11 Marie-Laure Ancelin 11 Sudha Seshadri 13 Rhoda Au 13 Alexa Beiser 14 Linda Lam 15 Candy Wong 15 Ada Fung 12, 15 Ki Kim 16, 17, 18 Ji Han 16 Tae Kim 16 Ronald Petersen 19 Rosebud Roberts 19 Michelle Mielke 19 Mary Ganguli 20, 21, 22 Hiroko Dodge 23, 24 Tiffany Hughes 20 Kaarin Anstey 25 Nicolas Cherbuin 25 Peter Butterworth 25 Tze Ng 26 Qi Gao 26 Simone Reppermund 1 Henry Brodaty 1, 2 Kenichi Meguro 27 Nicole Schupf 28, 29, 30 Jennifer Manly 28, 29, 31 Yaakov Stern 28, 29, 31 Antonio Lobo 32, 33, 34 Raúl Lopez-Anton 33, 35 Javier Santabárbara 33, 36
Abstract : BACKGROUND: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. DISCUSSION: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
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BMC Neurology, BioMed Central, 2013, 13 (1), pp.165. 〈10.1186/1471-2377-13-165〉
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Perminder Sachdev, Darren Lipnicki, Nicole Kochan, John Crawford, Kenneth Rockwood, et al.. COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.. BMC Neurology, BioMed Central, 2013, 13 (1), pp.165. 〈10.1186/1471-2377-13-165〉. 〈inserm-00904579〉

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