COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. - Archive ouverte HAL Access content directly
Journal Articles BMC Neurology Year : 2013

COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.

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Darren Lipnicki
  • Function : Author
  • PersonId : 948379
Nicole Kochan
  • Function : Author
  • PersonId : 948380
John Crawford
  • Function : Author
  • PersonId : 948381
Shifu Xiao
  • Function : Author
  • PersonId : 948383
Juan Li
  • Function : Author
  • PersonId : 948384
Xia Li
  • Function : Author
  • PersonId : 948385
Carol Brayne
  • Function : Author
  • PersonId : 948386
Fiona Matthews
  • Function : Author
  • PersonId : 948387
Blossom Stephan
  • Function : Author
  • PersonId : 948388
Mindy Katz
  • Function : Author
  • PersonId : 948390
Sudha Seshadri
  • Function : Author
  • PersonId : 948391
Rhoda Au
  • Function : Author
  • PersonId : 948392
Alexa Beiser
  • Function : Author
  • PersonId : 948393
Linda Lam
  • Function : Author
  • PersonId : 948394
Candy Wong
  • Function : Author
  • PersonId : 948395
Ada Fung
  • Function : Author
  • PersonId : 948396
Ji Won Han
  • Function : Author
  • PersonId : 948398
Tae Hui Kim
  • Function : Author
  • PersonId : 948399
Ronald Petersen
  • Function : Author
  • PersonId : 948400
Rosebud Roberts
  • Function : Author
  • PersonId : 948401
Michelle Mielke
  • Function : Author
  • PersonId : 948402
Hiroko Dodge
  • Function : Author
  • PersonId : 948404
Tiffany Hughes
  • Function : Author
  • PersonId : 948405
Tze Pin Ng
  • Function : Author
  • PersonId : 948409
Qi Gao
  • Function : Author
  • PersonId : 1057620
Simone Reppermund
  • Function : Author
  • PersonId : 948410
Kenichi Meguro
  • Function : Author
  • PersonId : 948412

Abstract

BACKGROUND: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. DISCUSSION: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
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Dates and versions

inserm-00904579 , version 1 (14-11-2013)

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Perminder Sachdev, Darren Lipnicki, Nicole Kochan, John Crawford, Kenneth Rockwood, et al.. COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.. BMC Neurology, 2013, 13 (1), pp.165. ⟨10.1186/1471-2377-13-165⟩. ⟨inserm-00904579⟩
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