RNA: a possible contributor to the 'missing heritability'

Abstract : A number of human pathologies have a transmission pattern that does not obey Mendelian segregation rules. This type of heredity is defined as non-Mendelian and is based on mechanisms of transgenerational epigenetic inheritance. Comprehensive information on the molecular mechanisms of it is still lacking. However, recent evidence from distantly related species including Caenorhabditis elegans, Drosophila, and mouse, points towards a role for non-coding RNA molecules in such a pattern of inheritance. While it would be too hasty to conclude that RNA molecules are at work in the transgenerational non-genetic inheritance of human pathologies, a growing number of studies seem to strongly support such a speculation.
Type de document :
Article dans une revue
Basic and Clinical Andrology, 2013, 23 (1), pp.9
Liste complète des métadonnées

Littérature citée [49 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00904366
Contributeur : Ed. Bmc <>
Soumis le : jeudi 14 novembre 2013 - 13:11:19
Dernière modification le : jeudi 11 janvier 2018 - 16:08:45
Document(s) archivé(s) le : samedi 15 février 2014 - 04:33:23

Fichiers

2051-4190-23-9.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

  • HAL Id : inserm-00904366, version 1

Collections

Citation

Valérie Grandjean, Danielle Badro, Jafar Kiani. RNA: a possible contributor to the 'missing heritability'. Basic and Clinical Andrology, 2013, 23 (1), pp.9. 〈inserm-00904366〉

Partager

Métriques

Consultations de la notice

218

Téléchargements de fichiers

153