RNA: a possible contributor to the 'missing heritability' - Archive ouverte HAL Access content directly
Journal Articles Basic and Clinical Andrology Year : 2013

RNA: a possible contributor to the 'missing heritability'

(1) , (1) , (1)
1

Abstract

A number of human pathologies have a transmission pattern that does not obey Mendelian segregation rules. This type of heredity is defined as non-Mendelian and is based on mechanisms of transgenerational epigenetic inheritance. Comprehensive information on the molecular mechanisms of it is still lacking. However, recent evidence from distantly related species including Caenorhabditis elegans, Drosophila, and mouse, points towards a role for non-coding RNA molecules in such a pattern of inheritance. While it would be too hasty to conclude that RNA molecules are at work in the transgenerational non-genetic inheritance of human pathologies, a growing number of studies seem to strongly support such a speculation.
Fichier principal
Vignette du fichier
2051-4190-23-9.pdf (327.7 Ko) Télécharger le fichier
Vignette du fichier
2051-4190-23-9.xml (65.05 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00904366 , version 1 (14-11-2013)

Identifiers

  • HAL Id : inserm-00904366 , version 1

Cite

Valérie Grandjean, Danielle Badro, Jafar Kiani. RNA: a possible contributor to the 'missing heritability'. Basic and Clinical Andrology, 2013, 23 (1), pp.9. ⟨inserm-00904366⟩
105 View
174 Download

Share

Gmail Facebook Twitter LinkedIn More