S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells.

Vincent Arnold 1 Jean-Saville Cummings 1 Uriel Moreno-Nieves 1 Céline Didier 1 Adrien Gilbert 1 Françoise Barré-Sinoussi 1 Daniel Scott-Algara 1, *
* Auteur correspondant
1 Régulation des Infections Rétrovirales
Abstract : BACKGROUND: The reportedly broad expression of CD85j across different immune cell types suggests an importance for this molecule in the human immune system. Previous reports have shown that this receptor interacts with several HLA class-I molecules, as well as with some viral proteins. We have demonstrated that the subset of CD85j + Natural Killer (NK) cells efficiently controls human immunodeficiency virus type 1 (HIV-1) replication in monocyte-derived dendritic cells (MDDC) in vitro and this led us to hypothesize that the CD85j + NK cell-mediated anti-HIV activity in MDDC is specifically dependent on the interaction between the CD85j receptor and unknown non-HLA class-I ligand(s). RESULTS: In this study, we focused our efforts on the identification of these non-described ligands for CD85j. We found that the CD85j receptor interacts with a calcium-binding proteins of the S100 family; namely, S100A9. We further demonstrated that HIV-1 infection of MDDC induces a modulation of S100A9 expression on surface of the MDDC, which potentially influences the anti-HIV-1 activity of human NK cells through a mechanism involving CD85j ligation. Additionally, we showed that stimulation of NK cells with exogenous S100A9 enhances the control of HIV-1 infection in CD4+ T cells. CONCLUSIONS: Our data show that S100A9 protein, through ligation with CD85j, can stimulate the anti-HIV-1 activity of NK cells.
Keywords : HIV-1 NK cells CD85j receptor Ligand S100A9 protein
Type de document :
Article dans une revue
Retrovirology, BioMed Central, 2013, 10 (1), pp.122. 〈10.1186/1742-4690-10-122〉
Liste complète des métadonnées

Littérature citée [35 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00904109
Contributeur : Ed. Bmc <>
Soumis le : mercredi 13 novembre 2013 - 17:08:34
Dernière modification le : mardi 19 novembre 2013 - 11:47:16

Fichiers

1742-4690-10-122.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

PASTEUR

Citation

Vincent Arnold, Jean-Saville Cummings, Uriel Moreno-Nieves, Céline Didier, Adrien Gilbert, et al.. S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells.. Retrovirology, BioMed Central, 2013, 10 (1), pp.122. 〈10.1186/1742-4690-10-122〉. 〈inserm-00904109〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

469

Téléchargements de fichiers

267

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD