Skip to Main content Skip to Navigation
Journal articles

Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study.: Diabetes risk scores and frailty

Abstract : OBJECTIVE: To examine whether established diabetes risk factors and diabetes risk algorithms are associated with future frailty. DESIGN: Prospective cohort study. Risk algorithms at baseline (1997-1999) were the Framingham Offspring, Cambridge, and Finnish diabetes risk scores. SETTING: Civil service departments in London, United Kingdom. PARTICIPANTS: There were 2707 participants (72% men) aged 45 to 69 years at baseline assessment and free of diabetes. MEASUREMENTS: Risk factors (age, sex, family history of diabetes, body mass index, waist circumference, systolic and diastolic blood pressure, antihypertensive and corticosteroid treatments, history of high blood glucose, smoking status, physical activity, consumption of fruits and vegetables, fasting glucose, HDL-cholesterol, and triglycerides) were used to construct the risk algorithms. Frailty, assessed during a resurvey in 2007-2009, was denoted by the presence of 3 or more of the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength, and weight loss; "prefrailty" was defined as having 2 or fewer of these indicators. RESULTS: After a mean follow-up of 10.5 years, 2.8% of the sample was classified as frail and 37.5% as prefrail. Increased age, being female, stopping smoking, low physical activity, and not having a daily consumption of fruits and vegetables were each associated with frailty or prefrailty. The Cambridge and Finnish diabetes risk scores were associated with frailty/prefrailty with odds ratios per 1 SD increase (disadvantage) in score of 1.18 (95% confidence interval: 1.09-1.27) and 1.27 (1.17-1.37), respectively. CONCLUSION: Selected diabetes risk factors and risk scores are associated with subsequent frailty. Risk scores may have utility for frailty prediction in clinical practice.
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download


https://www.hal.inserm.fr/inserm-00881129
Contributor : Dominique Villebrun <>
Submitted on : Tuesday, November 19, 2013 - 10:36:49 AM
Last modification on : Sunday, October 25, 2020 - 7:06:35 AM
Long-term archiving on: : Monday, March 3, 2014 - 1:56:45 PM

Files

Identifiers

Citation

Kim Bouillon, Mika Kivimäki, Mark Hamer, Martin Shipley, Tasnime Akbaraly, et al.. Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study.: Diabetes risk scores and frailty. Journal of the American Medical Directors Association, Elsevier, 2013, 14 (11), pp.851.e1-6. ⟨10.1016/j.jamda.2013.08.016⟩. ⟨inserm-00881129⟩

Share

Metrics

Record views

608

Files downloads

975