ALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors - Archive ouverte HAL Access content directly
Journal Articles Journal for Immunotherapy of Cancer Year : 2013

ALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors

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Abstract

The identification of unique cell-surface proteins expressed on tumor cells, yet not expressed on normal tissues, has been challenging for pediatric malignancies. The cell sur-face tyrosine kinase ALK (CD246, anaplastic lymphoma kinase) is a promising target for neuroblastoma in that it is expressed in either native, mutated, or over-expressed forms on the plasma membrane surface

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Life Sciences [q-bio] Cancer
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https://www.hal.inserm.fr/inserm-00881036

Submitted on : Thursday, November 7, 2013-1:14:47 PM

Last modification on : Sunday, June 26, 2022-9:48:41 AM

Long-term archiving on: Saturday, February 8, 2014-7:15:08 AM

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inserm-00881036 , version 1 (07-11-2013)

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Rimas Orentas, Paola Lopomo, William Babbitt, Marc Vigny, Crystal Mackall. ALK (anaplastic lymphoma kinase, CD246)-specific CARs: new immunotherapeutic agents for the treatment of pediatric solid tumors. Journal for Immunotherapy of Cancer, 2013, 1 (Suppl 1), pp.P27. ⟨10.1186/2051-1426-1-S1-P27⟩. ⟨inserm-00881036⟩

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