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Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis.: DHA & protectins against atherothrombosis

Abstract : DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1 g/d, DHA proved to be effective in lowering blood platelet function and exhibited an 'antioxidant' effect. However, this was no longer the case following 1*6 g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA.
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https://www.hal.inserm.fr/inserm-00879583
Contributor : Evelyne Vericel <>
Submitted on : Monday, November 4, 2013 - 12:28:15 PM
Last modification on : Wednesday, July 8, 2020 - 12:42:52 PM
Long-term archiving on: : Friday, April 7, 2017 - 8:24:14 PM

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Michel Lagarde, Miao Liu, Evelyne Véricel, Catherine Calzada, Ping Chen, et al.. Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis.: DHA & protectins against atherothrombosis. Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2013, pp.1-4. ⟨10.1017/S0029665113003704⟩. ⟨inserm-00879583⟩

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