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Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.

Abstract : BACKGROUND: The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria. METHODS: The association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes. RESULTS: In the ISOR sample, APOE epsilon4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than epsilon3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the epsilon4 and epsilon2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele. CONCLUSION: Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the epsilon4 allele on LDL-cholesterol levels in an Algerian population.
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Submitted on : Wednesday, October 30, 2013 - 5:09:01 PM
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Houssam Boulenouar, Sounnia Mediene Benchekor, Djabaria Naïma Meroufel, Sarah Aicha Lardjam Hetraf, Hadjira Ouhaibi Djellouli, et al.. Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.. Lipids in Health and Disease, BioMed Central, 2013, 12 (1), pp.155. ⟨10.1186/1476-511X-12-155⟩. ⟨inserm-00878749⟩



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