Macrophages: supportive cells for tissue repair and regeneration. - Archive ouverte HAL Access content directly
Journal Articles Immunobiology Year : 2014

Macrophages: supportive cells for tissue repair and regeneration.

(1)
1
Bénédicte Chazaud
  • Function : Correspondent author
  • PersonId : 936797

Connectez-vous pour contacter l'auteur

Abstract

Macrophages, and more broadly inflammation, have been considered for a long time as bad markers of tissue homeostasis. However, if it is indisputable that macrophages are associated with many diseases in a deleterious way, new roles have emerged, showing beneficial properties of macrophages during tissue repair and regeneration. This discrepancy is likely due to the high plasticity of macrophages, which may exhibit a wide range of phenotypes and functions depending on their environment. Therefore, regardless of their role in immunity, macrophages play a myriad of roles in the maintenance and recovery of tissue homeostasis. They take a major part in the resolution of inflammation. They also exert various effects of parenchymal cells, including stem and progenitor cell, of which they regulate the fate. In the present review, few examples from various tissues are presented to illustrate that, beyond their specific properties in a given tissue, common features have been described that sustain a role of macrophages in the recovery and maintenance of tissue homeostasis.
Fichier principal
Vignette du fichier
Immunobiology_re-Revised.pdf (601.69 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00877510 , version 1 (28-10-2013)

Identifiers

Cite

Bénédicte Chazaud. Macrophages: supportive cells for tissue repair and regeneration.. Immunobiology, 2014, 219 (3), pp.172-8. ⟨10.1016/j.imbio.2013.09.001⟩. ⟨inserm-00877510⟩
862 View
1397 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More