R. Stupp, W. Mason, M. Van-den-bent, M. Weller, and B. Fisher, Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.987-996, 2005.
DOI : 10.1056/NEJMoa043330

M. Dutreix, J. Cosset, and J. Sun, Molecular therapy in support to radiotherapy, Mutation Research/Reviews in Mutation Research, vol.704, issue.1-3, pp.182-189, 2010.
DOI : 10.1016/j.mrrev.2010.01.001

R. Jain, Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy, Science, vol.307, issue.5706, pp.58-62, 2005.
DOI : 10.1126/science.1104819

S. Combs, Radiation Therapy, Recent Results Cancer Res, vol.171, pp.125-140, 2009.
DOI : 10.1007/978-3-540-31206-2_7

K. Palanichamy and A. Chakravarti, Combining drugs and radiotherapy: from the bench to the bedside, Current Opinion in Neurology, vol.22, issue.6, pp.625-632, 2009.
DOI : 10.1097/WCO.0b013e3283327d33

Y. Zhu, J. Hu, Y. Hu, and W. Liu, Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance, Cancer Treatment Reviews, vol.35, issue.7, pp.590-596, 2009.
DOI : 10.1016/j.ctrv.2009.06.005

T. Jorgensen, Enhancing radiosensitivity: Targeting the DNA repair pathways, Cancer Biology & Therapy, vol.8, issue.8, pp.665-670, 2009.
DOI : 10.4161/cbt.8.8.8304

M. Kelley and M. Fishel, DNA Repair Proteins as Molecular Targets for Cancer Therapeutics, Anti-Cancer Agents in Medicinal Chemistry, vol.8, issue.4, pp.417-425, 2008.
DOI : 10.2174/187152008784220294

M. Quanz, D. Chassoux, N. Berthault, C. Agrario, and J. Sun, Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response, PLoS ONE, vol.4, issue.7, p.6298, 2009.
DOI : 10.1371/journal.pone.0006298.s005

M. Quanz, N. Berthault, C. Roulin, M. Roy, and A. Herbette, Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy, Clinical Cancer Research, vol.15, issue.4, pp.1308-1316, 2009.
DOI : 10.1158/1078-0432.CCR-08-2108

N. Berthault, M. B. Agrario, C. Herbette, A. Sun, and J. , Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems, Cancer Gene Therapy, vol.5, issue.10, pp.695-706, 2011.
DOI : 10.1016/j.cmpb.2009.08.008
URL : https://hal.archives-ouvertes.fr/hal-00683650

B. Schwartz, C. Benoist, B. Abdallah, R. Rangara, and A. Hassan, Gene transfer by naked DNA into adult mouse brain, Gene Ther, vol.3, pp.405-411, 1996.

R. Huang, Y. Qu, W. Ke, J. Zhu, and Y. Pei, Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer, The FASEB Journal, vol.21, issue.4, pp.1117-1125, 2007.
DOI : 10.1096/fj.06-7380com

L. Zhang, S. Zhu, L. Qian, Y. Pei, and Y. Qiu, RGD-modified PEG???PAMAM???DOX conjugates: In vitro and in vivo studies for glioma, European Journal of Pharmaceutics and Biopharmaceutics, vol.79, issue.2, pp.232-240, 2011.
DOI : 10.1016/j.ejpb.2011.03.025

Z. Hassani, G. Lemkine, P. Erbacher, K. Palmier, and G. Alfama, Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels, The Journal of Gene Medicine, vol.17, issue.2, pp.198-207, 2005.
DOI : 10.1002/jgm.659
URL : https://hal.archives-ouvertes.fr/hal-00181088

Y. Ko, R. Bhattacharya, and U. Bickel, Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting, Journal of Controlled Release, vol.133, issue.3, pp.230-237, 2009.
DOI : 10.1016/j.jconrel.2008.10.013

O. Boussif, F. Lezoualc-'h, M. Zanta, M. Mergny, and D. Scherman, A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine., Proceedings of the National Academy of Sciences, vol.92, issue.16, pp.7297-7301, 1995.
DOI : 10.1073/pnas.92.16.7297

Q. Chen, D. Butler, W. Querbes, R. Pandey, and P. Ge, Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery, Journal of Controlled Release, vol.144, issue.2, pp.227-232, 2010.
DOI : 10.1016/j.jconrel.2010.02.011

B. Lemasson, T. Christen, X. Tizon, R. Farion, and N. Fondraz, Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects, NMR in Biomedicine, vol.57, issue.(6 Suppl 16), pp.473-482, 2011.
DOI : 10.1002/nbm.1611
URL : https://hal.archives-ouvertes.fr/inserm-00607949

B. Lemasson, R. Serduc, C. Maisin, A. Bouchet, and N. Coquery, Monitoring Blood-Brain Barrier Status in a Rat Model of Glioma Receiving Therapy: Dual Injection of Low-Molecular-Weight and Macromolecular MR Contrast Media, Radiology, vol.257, issue.2, pp.342-352, 2010.
DOI : 10.1148/radiol.10092343
URL : https://hal.archives-ouvertes.fr/inserm-00589222

S. Valable, B. Lemasson, R. Farion, M. Beaumont, and C. Segebarth, study, NMR in Biomedicine, vol.90, issue.3, pp.1043-1056, 2008.
DOI : 10.1002/nbm.1278
URL : https://hal.archives-ouvertes.fr/inserm-00861168

X. Zhang, G. Sawyer, X. Dong, Y. Qiu, and L. Collins, Thein vivo use of chloroquine to promote non-viral gene delivery to the liver via the portal vein and bile duct, The Journal of Gene Medicine, vol.6, issue.3, pp.209-218, 2003.
DOI : 10.1002/jgm.340

C. Linard, C. Marquette, J. Mathieu, A. Pennequin, and D. Clarençon, Acute induction of inflammatory cytokine expression after ??-irradiation in the rat: Effect of an NF-??B inhibitor, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.2, pp.427-434, 2004.
DOI : 10.1016/j.ijrobp.2003.09.039

I. Troprès, L. Lamalle, M. Péoc-'h, R. Farion, and Y. Usson, In vivo assessment of tumoral angiogenesis, Magnetic Resonance in Medicine, vol.88, issue.Suppl, pp.533-541, 2004.
DOI : 10.1002/mrm.20017

N. Pannetier, B. Lemasson, T. Christen, M. Tachrount, and I. Troprès, Vessel size index measurements in a rat model of glioma: comparison of the dynamic (Gd) and steady-state (iron-oxide) susceptibility contrast MRI approaches, NMR in Biomedicine, vol.32, issue.2, pp.218-226, 2012.
DOI : 10.1002/nbm.1734
URL : https://hal.archives-ouvertes.fr/inserm-00658563

M. Keramidas, V. Josserand, C. Righini, C. Wenk, and C. Faure, Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model, British Journal of Surgery, vol.26, issue.5, pp.737-743, 2010.
DOI : 10.1002/bjs.6986

M. Beaumont, B. Lemasson, R. Farion, C. Segebarth, and C. Rémy, Characterization of Tumor Angiogenesis in Rat Brain Using Iron-Based Vessel Size Index MRI in Combination with Gadolinium-Based Dynamic Contrast-Enhanced MRI, Journal of Cerebral Blood Flow & Metabolism, vol.10, issue.10, pp.1714-1726, 2009.
DOI : 10.1002/nbm.881
URL : https://hal.archives-ouvertes.fr/inserm-00410316

C. Schlegel, F. Buhler, C. Devun, S. Agrario, and F. Urien, Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol, Molecular Therapy - Nucleic Acids, vol.1, 2012.
DOI : 10.1038/mtna.2012.27

W. Ng, Radiation-associated changes in tissues and tumours, Current Diagnostic Pathology, vol.9, issue.2, pp.124-136, 2003.
DOI : 10.1054/cdip.2003.0164

S. Oi, T. Kokunai, A. Ijichi, S. Matsumoto, and A. Raimondi, Radiation-induced Brain Damage in Children, Neurologia medico-chirurgica, vol.30, issue.1, pp.36-42, 1990.
DOI : 10.2176/nmc.30.36

J. Zawaski, M. Gaber, O. Sabek, C. Wilson, and C. Duntsch, Effects of Irradiation on Brain Vasculature Using an In Situ Tumor Model, International Journal of Radiation Oncology*Biology*Physics, vol.82, issue.3, 2012.
DOI : 10.1016/j.ijrobp.2011.06.1984

P. Pedersen, K. Edvardsen, I. Garcia-cabrera, R. Mahesparan, and J. Thorsen, Migratory patterns oflac-z transfected human glioma cells in the rat brain, International Journal of Cancer, vol.292, issue.6, pp.767-771, 1995.
DOI : 10.1002/ijc.2910620620

T. Tihan, J. Barletta, I. Parney, K. Lamborn, and P. Sneed, Prognostic value of detecting recurrent glioblastoma multiforme in surgical specimens from patients after radiotherapy: should pathology evaluation alter treatment decisions?, Human Pathology, vol.37, issue.3, pp.272-282, 2006.
DOI : 10.1016/j.humpath.2005.11.010

D. Macdonald, T. Cascino, S. Schold, . Jr, and J. Cairncross, Response criteria for phase II studies of supratentorial malignant glioma., Journal of Clinical Oncology, vol.8, issue.7, pp.1277-1280, 1990.
DOI : 10.1200/JCO.1990.8.7.1277

A. Brandes, E. Franceschi, A. Tosoni, V. Blatt, and A. Pession, Promoter Methylation Status Can Predict the Incidence and Outcome of Pseudoprogression After Concomitant Radiochemotherapy in Newly Diagnosed Glioblastoma Patients, Journal of Clinical Oncology, vol.26, issue.13, pp.2192-2197, 2008.
DOI : 10.1200/JCO.2007.14.8163

J. Vredenburgh, A. Desjardins, D. Reardon, K. Peters, and J. Herndon, The Addition of Bevacizumab to Standard Radiation Therapy and Temozolomide Followed by Bevacizumab, Temozolomide, and Irinotecan for Newly Diagnosed Glioblastoma, Clinical Cancer Research, vol.17, issue.12, pp.4119-4124, 2011.
DOI : 10.1158/1078-0432.CCR-11-0120

A. Lai, A. Tran, P. Nghiemphu, W. Pope, and O. Solis, Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme, Journal of Clinical Oncology, vol.29, issue.2, pp.142-148, 2011.
DOI : 10.1200/JCO.2010.30.2729

J. Stukel and M. Caplan, Targeted drug delivery for treatment and imaging of glioblastoma multiforme, Expert Opinion on Drug Delivery, vol.9, issue.7, pp.705-718, 2009.
DOI : 10.1007/s10439-008-9498-8

R. Jain, Transport of molecules across tumor vasculature, CANCER AND METASTASIS REVIEW, vol.47, issue.5, pp.559-593, 1987.
DOI : 10.1007/BF00047468

J. Rousseau, R. Barth, M. Moeschberger, and H. Elleaume, Efficacy of Intracerebral Delivery of Carboplatin in Combination With Photon Irradiation for Treatment of F98 Glioma-Bearing Rats, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.2, pp.530-536, 2009.
DOI : 10.1016/j.ijrobp.2008.09.018
URL : https://hal.archives-ouvertes.fr/inserm-00410447

E. Redgate, M. Deutsch, and S. Boggs, Time of death of CNS tumor-bearing rats can be reliably predicted by body weight-loss patterns, Lab Anim Sci, vol.41, pp.269-273, 1991.