Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Simon Ducheix; Alexandra Montagner; Arnaud Polizzi; Frédéric Lasserre; Alice Marmugi; Justine Bertrand-Michel; Normand Podechard; Talal Al Saati; Maud Chétiveaux; Silvère Baron; Jérôme Boué; Gilles Dietrich; Laila Mselli-Lakhal; Philippe Costet; Jean-Marc A. Lobaccaro; Thierry Pineau; Vassilia Theodorou; Catherine Postic; Pascal G.P. Martin; Hervé Guillou

doi:10.1016/j.jhep.2013.01.006

Journal articles

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Simon Ducheix ¹ Alexandra Montagner ¹ Arnaud Polizzi ² Frédéric Lasserre ² Alice Marmugi ¹ Justine Bertrand-Michel ³ Normand Podechard ⁴ Talal Al Saati ⁵ Maud Chétiveaux ⁶ Silvère Baron ^{7, 8} Jérôme Boué ⁹ Gilles Dietrich ⁹ Laila Mselli-Lakhal ¹⁰ Philippe Costet ⁶ Jean-Marc A. Lobaccaro ^{7, 8} Thierry Pineau ¹ Vassilia Theodorou ¹¹ Catherine Postic ¹² Pascal G.P. Martin ¹ Hervé Guillou ^{2, *}

* Corresponding author

1 ToxAlim - ToxAlim

2 ToxAlim-TIM - Toxicologie Intégrative & Métabolisme

ToxAlim - ToxAlim

3 Plateau MetaToul-LIPIDOMIQUE = MetaToul-Lipidomics

I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, MetaToul-MetaboHUB

4 SMS - Stress, membrane et signalisation

Irset - Institut de recherche en santé, environnement et travail

5 ANEXPLO

GENOTOUL - Génopole Toulouse Midi-Pyrénées [Auzeville], CREFRE - Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales, IPBS - Institut de pharmacologie et de biologie structurale

6 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291

7 GReD - Génétique, Reproduction et Développement

8 UNH - Unité de Nutrition Humaine

9 CPTP - Centre de Physiopathologie Toulouse Purpan

10 ToxAlim-EXPER - Exposition, Perturbation Endocrino-métabolique et Reproduction

ToxAlim - ToxAlim

11 ToxAlim-NGN - Neuro-Gastroentérologie & Nutrition

ToxAlim - ToxAlim

12 IC UM3 (UMR 8104 / U1016) - Institut Cochin

Abstract : BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.

Keywords : Lipogenesis Cholesterol LXR Polyunsaturated fatty acids Steatosis

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Hépatology and Gastroenterology

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https://www.hal.inserm.fr/inserm-00872314
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Submitted on : Friday, October 11, 2013 - 4:31:51 PM
Last modification on : Wednesday, January 12, 2022 - 2:24:05 PM

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

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Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

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