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Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Abstract : BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
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https://www.hal.inserm.fr/inserm-00872314
Contributor : Morgane Le Corre <>
Submitted on : Friday, October 11, 2013 - 4:31:51 PM
Last modification on : Saturday, September 26, 2020 - 9:10:03 AM

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Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Alice Marmugi, et al.. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.. Journal of Hepatology, Elsevier, 2013, 58 (5), pp.984-92. ⟨10.1016/j.jhep.2013.01.006⟩. ⟨inserm-00872314⟩

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