Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Abstract : BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
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Journal of Hepatology, Elsevier, 2013, 58 (5), pp.984-92. 〈10.1016/j.jhep.2013.01.006〉
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Contributeur : Morgane Le Corre <>
Soumis le : vendredi 11 octobre 2013 - 16:31:51
Dernière modification le : samedi 29 septembre 2018 - 12:48:02

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Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Alice Marmugi, et al.. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.. Journal of Hepatology, Elsevier, 2013, 58 (5), pp.984-92. 〈10.1016/j.jhep.2013.01.006〉. 〈inserm-00872314〉

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