Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor. - Archive ouverte HAL Access content directly
Journal Articles Journal of Hepatology Year : 2013

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

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Simon Ducheix
  • Function : Author
Alexandra Montagner
  • Function : Author
Arnaud Polizzi
  • Function : Author
  • PersonId : 872322
Frédéric Lasserre
  • Function : Author
  • PersonId : 1202853
Alice Marmugi
  • Function : Author
Talal Al Saati
  • Function : Author
Thierry Pineau
  • Function : Author
  • PersonId : 1202623
Catherine Postic
  • Function : Author
Pascal G.P. Martin

Abstract

BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
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Dates and versions

inserm-00872314 , version 1 (11-10-2013)

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Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Alice Marmugi, et al.. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.. Journal of Hepatology, 2013, 58 (5), pp.984-92. ⟨10.1016/j.jhep.2013.01.006⟩. ⟨inserm-00872314⟩
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