Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Simon Ducheix; Alexandra Montagner; Arnaud Polizzi; Frédéric Lasserre; Alice Marmugi; Justine Bertrand-Michel; Normand Podechard; Talal Al Saati; Maud Chétiveaux; Silvère Baron; Jérôme Boué; Gilles Dietrich; Laila Mselli-Lakhal; Philippe Costet; Jean-Marc A. Lobaccaro; Thierry Pineau; Vassilia Theodorou; Catherine Postic; Pascal Martin; Hervé Guillou

doi:10.1016/j.jhep.2013.01.006

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Simon Ducheix ¹ Alexandra Montagner ¹ Arnaud Polizzi ¹ Frédéric Lasserre ¹ Alice Marmugi ¹ Justine Bertrand-Michel ² Normand Podechard ³ Talal Al Saati ⁴ Maud Chétiveaux ⁵ Silvère Baron ^{6, 7} Jérôme Boué ⁸ Gilles Dietrich ⁸ Laila Mselli-Lakhal ¹ Philippe Costet ⁵ Jean-Marc A. Lobaccaro ^{6, 7} Thierry Pineau ¹ Vassilia Theodorou ¹ Catherine Postic ⁹ Pascal Martin ¹ Hervé Guillou ^{1, *}

* Auteur correspondant

1 ToxAlim - ToxAlim

2 Plateau MetaToul-LIPIDOMIQUE

3 SMS - Stress, membrane et signalisation

Irset - Institut de recherche, santé, environnement et travail

4 ANEXPLO / CREFRE

5 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291

6 GReD - Génétique, reproduction et développement

7 UNH - Unité de Nutrition Humaine

8 CPTP - Centre de Physiopathologie de Toulouse Purpan

9 UM3 (UMR 8104 / U1016) - Institut Cochin

Abstract : BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.

Keywords : Lipogenesis Cholesterol LXR Polyunsaturated fatty acids Steatosis

Type de document :

Article dans une revue

Journal of Hepatology, Elsevier, 2013, 58 (5), pp.984-92. 〈10.1016/j.jhep.2013.01.006〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Hépatologie et Gastroentérologie

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00872314
Contributeur : Morgane Le Corre <>
Soumis le : vendredi 11 octobre 2013 - 16:31:51
Dernière modification le : samedi 29 septembre 2018 - 12:48:02

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

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Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

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