M. Liesa, M. Palacin, and A. Zorzano, Mitochondrial Dynamics in Mammalian Health and Disease, Physiological Reviews, vol.89, issue.3, pp.799-845, 2009.
DOI : 10.1152/physrev.00030.2008

F. Legros, A. Lombes, P. Frachon, and M. Rojo, Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins, Molecular Biology of the Cell, vol.13, issue.12, pp.4343-4354, 2002.
DOI : 10.1091/mbc.E02-06-0330

A. Olichon, L. Emorine, E. Descoins, L. Pelloquin, L. Brichese et al., The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space, FEBS Letters, vol.2, issue.1-3, pp.171-176, 2002.
DOI : 10.1016/S0014-5793(02)02985-X

C. Alexander, M. Votruba, U. Pesch, D. Thiselton, S. Mayer et al., OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nature Genetics, vol.132, issue.2, pp.211-215, 2000.
DOI : 10.1146/annurev.bi.50.070181.002025

C. Delettre, G. Lenaers, J. Griffoin, N. Gigarel, C. Lorenzo et al., Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nature Genetics, vol.303, issue.2, pp.207-210, 2000.
DOI : 10.1083/JCB.143.2.351

S. Zuchner, I. Mersiyanova, M. Muglia, N. Bissar-tadmouri, J. Rochelle et al., Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, Nature Genetics, vol.8, issue.5, pp.449-451, 2004.
DOI : 10.1083/jcb.200209124

M. Votruba, A. Moore, and S. Bhattacharya, Clinical features, molecular genetics, and pathophysiology of dominant optic atrophy., Journal of Medical Genetics, vol.35, issue.10, pp.793-800, 1998.
DOI : 10.1136/jmg.35.10.793

C. Delettre, J. Griffoin, J. Kaplan, H. Dollfus, B. Lorenz et al., Mutation spectrum and splicing variants in the OPA1 gene, Human Genetics, vol.109, issue.6, pp.584-591, 2001.
DOI : 10.1007/s00439-001-0633-y

A. Kaasik, V. Veksler, E. Boehm, M. Novotova, A. Minajeva et al., Energetic Crosstalk Between Organelles: Architectural Integration of Energy Production and Utilization, Circulation Research, vol.89, issue.2, pp.153-159, 2001.
DOI : 10.1161/hh1401.093440

J. Wilding, F. Joubert, C. De-araujo, D. Fortin, M. Novotova et al., Altered energy transfer from mitochondria to sarcoplasmic reticulum after cytoarchitectural perturbations in mice hearts, The Journal of Physiology, vol.539, issue.134, pp.191-200, 2006.
DOI : 10.1113/jphysiol.2006.114116
URL : https://hal.archives-ouvertes.fr/inserm-00083079

J. Piquereau, M. Novotova, D. Fortin, A. Garnier, R. Ventura-clapier et al., Postnatal development of mouse heart: formation of energetic microdomains, The Journal of Physiology, vol.575, issue.134, pp.2443-2454, 2010.
DOI : 10.1113/jphysiol.2010.189670

R. Ventura-clapier, A. Garnier, and V. Veksler, Energy metabolism in heart failure, The Journal of Physiology, vol.543, issue.1, pp.1-13, 2004.
DOI : 10.1113/jphysiol.2003.055095
URL : https://hal.archives-ouvertes.fr/inserm-00290146

R. Ventura-clapier, A. Garnier, V. Veksler, and F. Joubert, Bioenergetics of the failing heart, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1813, issue.7, pp.1360-1372, 2011.
DOI : 10.1016/j.bbamcr.2010.09.006

S. Ong and D. Hausenloy, Mitochondrial morphology and cardiovascular disease, Cardiovascular Research, vol.88, issue.1, pp.16-29, 2010.
DOI : 10.1093/cvr/cvq237
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936127

P. Shahrestani, H. Leung, P. Le, W. Pak, S. Tse et al., Heterozygous Mutation of Drosophila Opa1 Causes the Development of Multiple Organ Abnormalities in an Age-Dependent and Organ-Specific Manner, PLoS ONE, vol.264, issue.8, p.6867, 2009.
DOI : 10.1371/journal.pone.0006867.s001

G. Dorn, C. Clark, W. Eschenbacher, M. Kang, J. Engelhard et al., MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila, Circulation Research, vol.108, issue.1, pp.12-17, 2011.
DOI : 10.1161/CIRCRESAHA.110.236745

L. Chen, Q. Gong, J. Stice, and A. Knowlton, Mitochondrial OPA1, apoptosis, and heart failure, Cardiovascular Research, vol.84, issue.1, pp.91-99, 2009.
DOI : 10.1093/cvr/cvp181
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741347

M. Alavi, S. Bette, S. Schimpf, F. Schuettauf, U. Schraermeyer et al., A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy, Brain, vol.130, issue.4, pp.1029-1042, 2007.
DOI : 10.1093/brain/awm005

M. Alavi, N. Fuhrmann, H. Nguyen, P. Yu-wai-man, P. Heiduschka et al., Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy, Experimental Neurology, vol.220, issue.2, pp.404-409, 2009.
DOI : 10.1016/j.expneurol.2009.09.026

P. Heiduschka, S. Schnichels, N. Fuhrmann, S. Hofmeister, U. Schraermeyer et al., -Associated Autosomal Dominant Optic Atrophy, Investigative Opthalmology & Visual Science, vol.51, issue.3, pp.1424-1431, 2010.
DOI : 10.1167/iovs.09-3606

I. Verde, G. Vandecasteele, F. Lezoualc-'h, and R. Fischmeister, current in rat ventricular myocytes, British Journal of Pharmacology, vol.484, issue.Suppl. 2, pp.65-74, 1999.
DOI : 10.1038/sj.bjp.0702506

A. Kuznetsov, V. Veksler, F. Gellerich, V. Saks, R. Margreiter et al., Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells, Nature Protocols, vol.444, issue.6, pp.965-976, 2008.
DOI : 10.1038/nprot.2008.61

F. Joubert, J. Wilding, D. Fortin, V. Domergue-dupont, M. Novotova et al., Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure, The Journal of Physiology, vol.517, issue.134, pp.5181-5192, 2008.
DOI : 10.1113/jphysiol.2008.157677
URL : https://hal.archives-ouvertes.fr/inserm-00325088

J. Palmer, B. Tandler, and C. Hoppel, Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle, J Biol Chem, vol.252, pp.8731-8739, 1977.

A. Belzacq-casagrande, C. Martel, C. Pertuiset, A. Borgne-sanchez, E. Jacotot et al., Pharmacological screening and enzymatic assays for apoptosis, Frontiers in Bioscience, vol.Volume, issue.14, pp.3550-3562, 2009.
DOI : 10.2741/3470
URL : https://hal.archives-ouvertes.fr/hal-00354311

L. Fang, X. Moore, X. Gao, A. Dart, Y. Lim et al., Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo, Life Sciences, vol.80, issue.23, pp.2154-2160, 2007.
DOI : 10.1016/j.lfs.2007.04.003

N. Beraud, S. Pelloux, Y. Usson, A. Kuznetsov, X. Ronot et al., Mitochondrial dynamics in heart cells: Very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells, Journal of Bioenergetics and Biomembranes, vol.95, issue.257, pp.195-214, 2009.
DOI : 10.1007/s10863-009-9214-x
URL : https://hal.archives-ouvertes.fr/hal-00380282

S. Ong, S. Subrayan, S. Lim, D. Yellon, S. Davidson et al., Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury, Circulation, vol.121, issue.18, pp.2012-2022, 2010.
DOI : 10.1161/CIRCULATIONAHA.109.906610

K. Papanicolaou, R. Khairallah, G. Ngoh, A. Chikando, I. Luptak et al., Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes, Molecular and Cellular Biology, vol.31, issue.6, pp.1309-1328, 2011.
DOI : 10.1128/MCB.00911-10

C. Frezza, S. Cipolat, O. Martins-de-brito, M. Micaroni, G. Beznoussenko et al., OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion, Cell, vol.126, issue.1, pp.177-189, 2006.
DOI : 10.1016/j.cell.2006.06.025

H. Chen, S. Detmer, A. Ewald, E. Griffin, S. Fraser et al., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development, The Journal of Cell Biology, vol.114, issue.2, pp.189-200, 2003.
DOI : 10.1016/S1357-4310(98)01293-3

S. Cipolat, O. Martins-de-brito, D. Zilio, B. Scorrano, and L. , OPA1 requires mitofusin 1 to promote mitochondrial fusion, Proceedings of the National Academy of Sciences, vol.101, issue.45, pp.15927-15932, 2004.
DOI : 10.1073/pnas.0407043101

A. Olichon, L. Baricault, N. Gas, E. Guillou, A. Valette et al., Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis, Journal of Biological Chemistry, vol.278, issue.10, pp.7743-7746, 2003.
DOI : 10.1074/jbc.C200677200

V. Saks, A. Kuznetsov, T. Andrienko, Y. Usson, F. Appaix et al., Heterogeneity of ADP Diffusion and Regulation of Respiration in Cardiac Cells, Biophysical Journal, vol.84, issue.5, pp.3436-3456, 2003.
DOI : 10.1016/S0006-3495(03)70065-4
URL : https://hal.archives-ouvertes.fr/hal-00192522

V. Mayorov, A. Lowrey, V. Biousse, N. Newman, S. Cline et al., Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy, BMC Biochemistry, vol.9, issue.1, p.22, 2008.
DOI : 10.1186/1471-2091-9-22

H. Chen, A. Chomyn, and D. Chan, Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction, Journal of Biological Chemistry, vol.280, issue.28, pp.26185-26192, 2005.
DOI : 10.1074/jbc.M503062200

J. Elrod, R. Wong, S. Mishra, R. Vagnozzi, B. Sakthievel et al., Cyclophilin D controls mitochondrial pore???dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice, Journal of Clinical Investigation, vol.120, issue.10, pp.3680-3687, 2010.
DOI : 10.1172/JCI43171DS1

V. Nogueira, D. A. Walter, L. Rigoulet, M. Leverve, X. Fontaine et al., Effects of Decreasing Mitochondrial Volume on the Regulation of the Permeability Transition Pore, Journal of Bioenergetics and Biomembranes, vol.1241, issue.1, pp.25-33, 2005.
DOI : 10.1007/s10863-005-4120-3
URL : https://hal.archives-ouvertes.fr/inserm-00388765

T. Iijima, K. Tanaka, S. Matsubara, H. Kawakami, T. Mishima et al., Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model, Neuroscience Letters, vol.448, issue.3, pp.268-272, 2008.
DOI : 10.1016/j.neulet.2008.10.056

M. Wasilewski and L. Scorrano, The changing shape of mitochondrial apoptosis, Trends in Endocrinology & Metabolism, vol.20, issue.6, pp.287-294, 2009.
DOI : 10.1016/j.tem.2009.03.007

M. Sun, J. Williams, C. Munoz-pinedo, G. Perkins, J. Brown et al., Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis, Nature Cell Biology, vol.1763, issue.9, pp.1057-1065, 2007.
DOI : 10.1091/mbc.E04-04-0294