Sphingolipids and response to chemotherapy.

Marie-Thérèse Dimanche-Boitrel 1, * Amélie Rébillard 2
* Auteur correspondant
1 SMS - Stress, membrane et signalisation
Irset - Institut de recherche, santé, environnement et travail
Abstract : Chemotherapy is frequently used to treat primary or metastatic cancers, but intrinsic or acquired drug resistance limits its efficiency. Sphingolipids are important regulators of various cellular processes including proliferation, apoptosis, differentiation, angiogenesis, stress, and inflammatory responses which are linked to various aspects of cancer, like tumor growth, neoangiogenesis, and response to chemotherapy. Ceramide, the central molecule of sphingolipid metabolism, generally mediates antiproliferative and proapoptotic functions, whereas sphingosine-1-phosphate and other derivatives have opposing effects. Among the variety of enzymes that control ceramide generation, acid or neutral sphingomyelinases and ceramide synthases are important targets to allow killing of cancer cells by chemotherapeutic drugs. On the contrary, glucosylceramide synthase, ceramidase, and sphingosine kinase are other targets driving cancer cell resistance to chemotherapy. This chapter focuses on ceramide-based mechanisms leading to cancer therapy sensitization or resistance which could have some impacts on the development of novel cancer therapeutic strategies.
Type de document :
Article dans une revue
Handb Exp Pharmacol, Vsevolod Gurevich, 2013, 216, pp.73-91. 〈10.1007/978-3-7091-1511-4_4〉
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Contributeur : Morgane Le Corre <>
Soumis le : mercredi 9 octobre 2013 - 15:03:50
Dernière modification le : mercredi 18 juillet 2018 - 20:02:03



Marie-Thérèse Dimanche-Boitrel, Amélie Rébillard. Sphingolipids and response to chemotherapy.. Handb Exp Pharmacol, Vsevolod Gurevich, 2013, 216, pp.73-91. 〈10.1007/978-3-7091-1511-4_4〉. 〈inserm-00871347〉



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