Modulation of the TCR stimulation strength can render human activated CD4+ T cells suppressive.

Abstract : In this study, we explored the potential of human naive CD4(+) T cells to acquire regulatory properties upon stimulation. We demonstrated that, in vitro, pre-activated naive CD4(+)CD25(-)CD45RA(+) T cells could become anergic and suppressive CD4(+)CD25(+) T cells upon lower intensity TCR stimulation. These CD4(+)CD25(+) T cells generated in vitro potently suppress the proliferation of allogenic CD4(+)CD25(-) T cells independently of cytokines and in a contact-dependent manner. Our data indicate that expression of Foxp3 is not necessary to induce the suppressive T cell activity. We demonstrate that these CD4(+)CD25(+) T cells are unresponsive upon re-stimulation and that their suppressive activity is transient. However, we showed that the anergy and the suppressive function could be reversed by increasing the stimulus and their level of activation. We concluded from our data that these anergy and suppressive activities are related to a fine tuning of TCR activation threshold.
Type de document :
Article dans une revue
International Immunology, Oxford University Press (OUP), 2009, 21 (9), pp.1025-36. 〈10.1093/intimm/dxp068〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00869416
Contributeur : Morgane Le Corre <>
Soumis le : jeudi 3 octobre 2013 - 11:35:15
Dernière modification le : mercredi 16 mai 2018 - 11:23:19

Lien texte intégral

Identifiants

Collections

Citation

Grégory Noël, Carine Brinster, Gilbert Semana, Denis Bruniquel. Modulation of the TCR stimulation strength can render human activated CD4+ T cells suppressive.. International Immunology, Oxford University Press (OUP), 2009, 21 (9), pp.1025-36. 〈10.1093/intimm/dxp068〉. 〈inserm-00869416〉

Partager

Métriques

Consultations de la notice

79