Skip to Main content Skip to Navigation
Journal articles

Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial.

Abstract : BACKGROUND: The Montpellier cancer institute phase II trial started in 2004 and evaluated the feasibility of intraoperative radiotherapy (IORT) technique given as a sole radiation treatment for patients with an excellent prognostic and very low recurrence risk. METHODS: Forty-two patients were included between 2004 and 2007. Inclusion criteria were patients >= 65 years old, T0-T1, N0, ductal invasive unifocal carcinoma, free-margin > 2 mm. IORT was delivered using dedicated linear accelerator. One fraction of 21 Gy was prescribed and specified at the 90% isodose using electrons. In vivo dosimetry was performed for all patients. Primary end-point was the quality index. Secondary endpoints were quality of life, local recurrences, cosmetic results, specific and overall survival. RESULTS: At inclusion, median age was 72 years (range, 66--80). Median tumor diameter was 10 mm. All patients received the total prescribed dose. No acute grade 3 toxicities were observed. Late cosmetic results were good at 5 years despite the poor agreement of accuracy assessment between patients and physicians. Four patients (9.5%) experienced a local failure and underwent salvage mastectomy. The 5 year-disease free survival is 92.7% (range 79.1-97.6). All patients are still alive with a median follow-up of 72 months (range 66--74). CONCLUSION: Our results confirm with a long-term follow-up that exclusive partial breast IORT is feasible for early-breast cancer in selected patients. IORT provides good late cosmetics results and should be considered as a safe and very comfortable "one-step" treatment procedure. Nevertheless, patient assessments are essential for long-term quality results.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00869332
Contributor : Ed. Bmc <>
Submitted on : Thursday, October 3, 2013 - 6:10:27 AM
Last modification on : Friday, October 23, 2020 - 4:59:07 PM
Long-term archiving on: : Monday, January 6, 2014 - 10:01:37 AM

Files

Identifiers

Collections

Citation

Claire Lemanski, David Azria, Sophie Gourgou-Bourgade, Norbert Ailleres, Aurelie Pastant, et al.. Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial.. Radiation Oncology, BioMed Central, 2013, 8 (1), pp.191. ⟨10.1186/1748-717X-8-191⟩. ⟨inserm-00869332⟩

Share

Metrics

Record views

414

Files downloads

697