Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice
Résumé
Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent protein kinase). Increased activated PKR levels were found in AD patients brain and cerebrospinal fluid. PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro. Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process?
Fichier principal
1750-1326-8-S1-P32.pdf (170.95 Ko)
Télécharger le fichier
1750-1326-8-S1-P32.xml (4.09 Ko)
Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre