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Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

Abstract : Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent protein kinase). Increased activated PKR levels were found in AD patients brain and cerebrospinal fluid. PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro. Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process?
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https://www.hal.inserm.fr/inserm-00868758
Contributor : Ed. Bmc <>
Submitted on : Tuesday, October 1, 2013 - 9:50:06 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:03 AM
Long-term archiving on: : Thursday, January 2, 2014 - 11:35:13 AM

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François Mouton-Liger, Anne-Sophie Rebillat, Clarisse Pace, Sarah Gourmaud, Mariko Taga, et al.. Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice. Molecular Neurodegeneration, BioMed Central, 2013, 8 (Suppl 1), pp.P32. ⟨10.1186/1750-1326-8-S1-P32⟩. ⟨inserm-00868758⟩

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