Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism - Archive ouverte HAL Access content directly
Journal Articles Molecular Neurodegeneration Year : 2013

Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

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Abstract

Abnormalities in oxidativemetabolism, inflammation,and selective neuronal death are described features of Alzheimer 's disease (AD) pathology. Brain thiamine-dependent enzymes play an important role in energy metabolism and display reduced activity in AD. Thiamine (vitamin B1) deficiency (TD) induces regionally selective neuronal death in animal and human brains.

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Life Sciences [q-bio] Neurons and Cognition [q-bio.NC] Neurobiology Life Sciences [q-bio] Neurons and Cognition [q-bio.NC]
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Submitted on : Tuesday, October 1, 2013-9:49:59 PM

Last modification on : Sunday, June 26, 2022-9:45:43 AM

Long-term archiving on: Thursday, January 2, 2014-11:30:14 AM

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inserm-00868757 , version 1 (01-10-2013)

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François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud, Audrey Leguen, Claire Paquet, et al.. Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism. Molecular Neurodegeneration, 2013, 8 (Suppl 1), pp.P31. ⟨10.1186/1750-1326-8-S1-P31⟩. ⟨inserm-00868757⟩

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