Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects. - Archive ouverte HAL Access content directly
Journal Articles Cardiovascular Diabetology Year : 2013

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects.

(1) , (1) , (1) , (1, 2) , (3) , (1) , (4) , (5) , (1)
1
2
3
4
5
Pedro Saddi-Rosa
  • Function : Author
  • PersonId : 946136
Carolina Soares Oliveira
  • Function : Author
  • PersonId : 946137
Felipe Crispim
  • Function : Author
  • PersonId : 946138
Valter Correia de Lima
  • Function : Author
  • PersonId : 946140
José Gilberto Vieira
  • Function : Author
  • PersonId : 946141
Alessandro Doria
  • Function : Author
  • PersonId : 946142
André Fernandes Reis
  • Function : Correspondent author
  • PersonId : 946144

Connectez-vous pour contacter l'auteur

Abstract

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor and a potential regulatory factor in inflammatory and immune processes. Associations of circulating NAMPT levels with cardiovascular disease (CVD) and insulin resistance have been reported. We investigated association of circulating NAMPT levels and the rs9770242 NAMPT gene polymorphism with coronary artery disease (CAD). METHODS: We studied 594 Brazilian subjects undergoing a coronary angiography (49% of whom had type 2 diabetes). CAD, defined as stenosis greater than 50% in one major coronary vessel or branch, was observed in 68% of subjects. Genetic studies were also performed in 858 North-American Non-Hispanic White subjects with type 2 diabetes (49% with CAD). RESULTS: We observed an interaction between glycemic and CAD status on the comparison of NAMPT levels by CAD status. NAMPT levels were higher in type 2 diabetic patients with CAD as compared to those without CAD: 5.27 +/- 2.93 ng/ml vs. 4.43 +/- 2.94 ng/ml, p = 0.006 (mean +/- SD). NAMPT levels were not significantly different in non-diabetic subjects with or without CAD. The T-allele of rs9770242 was associated with CAD in the Brazilian cohort (OR 1.46, 95% CI 1.06 - 2.01, p = 0.02) while no association was observed in the North-American cohort. CONCLUSIONS: Our data suggest that circulating NAMPT levels are associated with CAD in type 2 diabetic patients. NAMPT rs9770242 polymorphism may be associated with CAD in some populations.
Fichier principal
Vignette du fichier
1475-2840-12-119.pdf (174.84 Ko) Télécharger le fichier
Vignette du fichier
1475-2840-12-119.xml (93.11 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00868742 , version 1 (01-10-2013)

Identifiers

Cite

Pedro Saddi-Rosa, Carolina Soares Oliveira, Felipe Crispim, Fernando Giuffrida, Valter Correia de Lima, et al.. Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects.. Cardiovascular Diabetology, 2013, 12 (1), pp.119. ⟨10.1186/1475-2840-12-119⟩. ⟨inserm-00868742⟩
270 View
433 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More