Y. Hinuma, H. Komoda, T. Chosa, T. Kondo, M. Kohakura et al., Antibodies to adult t-cell leukemia-virus-associated antigen (atla) in sera from patients with atl and controls in japan: A nation-wide sero-epidemiologic study, International Journal of Cancer, vol.79, issue.6, pp.631-635, 1982.
DOI : 10.1002/ijc.2910290606

B. Poiesz, F. Ruscetti, A. Gazdar, P. Bunn, J. Minna et al., Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proceedings of the National Academy of Sciences, vol.77, issue.12, pp.7415-7419, 1980.
DOI : 10.1073/pnas.77.12.7415

A. Bazarbachi, D. Ghez, Y. Lepelletier, R. Nasr, H. De-the et al., New therapeutic approaches for adult T-cell leukaemia, The Lancet Oncology, vol.5, issue.11, pp.664-672, 2004.
DOI : 10.1016/S1470-2045(04)01608-0
URL : https://hal.archives-ouvertes.fr/hal-00098158

A. Bazarbachi, F. Suarez, P. Fields, and H. O. , How I treat adult T-cell leukemia/lymphoma, Blood, vol.118, issue.7, pp.1736-1745, 2011.
DOI : 10.1182/blood-2011-03-345702
URL : https://hal.archives-ouvertes.fr/hal-00610253

K. Tsukasaki, O. Hermine, A. Bazarbachi, L. Ratner, J. Ramos et al., Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting, Journal of Clinical Oncology, vol.27, issue.3, pp.453-459, 2009.
DOI : 10.1200/JCO.2008.18.2428
URL : https://hal.archives-ouvertes.fr/hal-00356513

O. Hermine, E. Wattel, A. Gessain, and A. Bazarbachi, Adult T Cell Leukaemia, BioDrugs, vol.10, issue.6, pp.447-462, 1998.
DOI : 10.2165/00063030-199810060-00003
URL : https://hal.archives-ouvertes.fr/hal-00098158

B. Hanchard, Adult T-cell leukemia/lymphoma in Jamaica, pp.1986-1995

P. Bunn, . Jr, G. Schechter, E. Jaffe, D. Blayney et al., Clinical Course of Retrovirus-Associated Adult T-Cell Lymphoma in the United States, New England Journal of Medicine, vol.309, issue.5, pp.257-264, 1983.
DOI : 10.1056/NEJM198308043090501

F. Takatsuki, K. Yamaguchi, and T. Hattori, Adult T-cell leukemia/lymphoma., Retrovirus biology and human disease, pp.147-159, 1990.
DOI : 10.2169/naika.74.1210

J. Richardson, A. Edwards, J. Cruickshank, P. Rudge, and A. Dalgleish, In vivo cellular tropism of human T-cell leukemia virus type 1, J Virol, vol.64, pp.5682-5687, 1990.

N. Araya, T. Sato, N. Yagishita, H. Ando, A. Utsunomiya et al., Human T-Lymphotropic Virus Type 1 (HTLV-1) and Regulatory T Cells in HTLV-1-Associated??Neuroinflammatory Disease, Viruses, vol.3, issue.12, pp.1532-1548, 2011.
DOI : 10.3390/v3091532

S. Hori, T. Nomura, and S. Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3, Science, vol.299, issue.5609, pp.1057-1061, 2003.
DOI : 10.1126/science.1079490

S. Sakaguchi, Regulatory T cells in the past and for the future, European Journal of Immunology, vol.123, issue.4, pp.901-937, 2008.
DOI : 10.1002/eji.200890012

Y. Yamada, Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma, Blood, vol.61, pp.192-199, 1983.

T. Kohno, Y. Yamada, N. Akamatsu, S. Kamihira, Y. Imaizumi et al., Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells, Cancer Science, vol.70, issue.8, pp.527-533, 2005.
DOI : 10.1006/viro.1993.1451

S. Chen, N. Ishii, S. Ine, S. Ikeda, T. Fujimura et al., Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells, International Immunology, vol.18, issue.2, pp.269-277, 2006.
DOI : 10.1093/intimm/dxh366

Y. Matsubara, T. Hori, R. Morita, S. Sakaguchi, and T. Uchiyama, Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells, Leukemia, vol.19, issue.3, pp.482-483, 2005.
DOI : 10.1038/sj.leu.2403628

M. Shimoyama, Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma., British Journal of Haematology, vol.68, issue.3, pp.428-437, 1991.
DOI : 10.1002/ijc.2910450206

A. Bazarbachi and O. Hermine, Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives, Virus Research, vol.78, issue.1-2, pp.79-92, 2001.
DOI : 10.1016/S0168-1702(01)00286-6

K. Tobinai, Current management of adult T-cell leukemia/lymphoma, Oncology, vol.23, pp.1250-1256, 2009.

H. Taguchi, K. Kinoshita, K. Takatsuki, M. Tomonaga, K. Araki et al., An Intensive Chemotherapy of Adult T-Cell Leukemia/Lymphoma: CHOP Followed by Etoposide, Vindesine, Ranimustine, and Mitoxantrone with Granulocyte Colony-Stimulating Factor Support, Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol.12, issue.2, pp.182-186, 1996.
DOI : 10.1097/00042560-199606010-00012

Y. Yamada, M. Tomonaga, H. Fukuda, S. Hanada, A. Utsunomiya et al., A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303, British Journal of Haematology, vol.3, issue.2, pp.375-382, 2001.
DOI : 10.1038/sj.bmt.1701002

Y. Takasaki, M. Iwanaga, Y. Imaizumi, M. Tawara, T. Joh et al., Long-term study of indolent adult T-cell leukemia-lymphoma, Blood, vol.115, issue.22, pp.4337-4343, 2010.
DOI : 10.1182/blood-2009-09-242347

A. Bazarbachi, Y. Plumelle, C. Ramos, J. Tortevoye, P. Otrock et al., Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes, Journal of Clinical Oncology, vol.28, issue.27, pp.4177-4183, 2010.
DOI : 10.1200/JCO.2010.28.0669
URL : https://hal.archives-ouvertes.fr/pasteur-00531240

A. Bazarbachi, M. El-sabban, R. Nasr, F. Quignon, C. Awaraji et al., Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells, Blood, vol.93, pp.278-283, 1999.

M. El-sabban, R. Nasr, G. Dbaibo, O. Hermine, N. Abboushi et al., Arsenic-interferon-alphatriggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation, Blood, vol.96, pp.2849-2855, 2000.

R. Nasr, A. Rosenwald, M. El-sabban, B. Arnulf, P. Zalloua et al., Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells, Blood, vol.101, issue.11, pp.4576-4582, 2003.
DOI : 10.1182/blood-2002-09-2986

O. Hermine, H. Dombret, J. Poupon, B. Arnulf, F. Lefrere et al., Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma, The Hematology Journal, vol.5, issue.2, pp.130-134, 2004.
DOI : 10.1038/sj.thj.6200374
URL : https://hal.archives-ouvertes.fr/hal-00102125

E. Hajj, H. El-sabban, M. Hasegawa, H. Zaatari, G. Ablain et al., Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia, The Journal of Experimental Medicine, vol.11, issue.13, pp.2785-2792, 2010.
DOI : 10.1073/pnas.94.8.3978

G. Kchour, M. Tarhini, M. Kooshyar, H. Hajj, E. Wattel et al., Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL), Blood, vol.113, issue.26, pp.6528-6532, 2009.
DOI : 10.1182/blood-2009-03-211821
URL : https://hal.archives-ouvertes.fr/hal-00408123

A. Inagaki, T. Ishida, T. Ishii, H. Komatsu, S. Iida et al., Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: High interleukin-5 and -10 levels are significant unfavorable prognostic factors, International Journal of Cancer, vol.43, issue.12, pp.3054-3061, 2006.
DOI : 10.1002/ijc.21688

P. Vieira, J. Christensen, S. Minaee, O. Neill, E. Barrat et al., IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells, The Journal of Immunology, vol.172, issue.10, pp.5986-5993, 2004.
DOI : 10.4049/jimmunol.172.10.5986

K. Karube, K. Ohshima, T. Tsuchiya, T. Yamaguchi, R. Kawano et al., Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells

F. Toulza, K. Nosaka, M. Takiguchi, T. Pagliuca, H. Mitsuya et al., regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia, International Journal of Cancer, vol.64, issue.10, pp.2375-2382, 2009.
DOI : 10.1002/ijc.24664

G. Roncador, J. Garcia, L. Maestre, E. Lucas, J. Menarguez et al., FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma, Leukemia, vol.11, issue.12, pp.2247-2253, 2005.
DOI : 10.1038/nm1093

Y. Yamano, N. Araya, T. Sato, A. Utsunomiya, K. Azakami et al., Abnormally High Levels of Virus-Infected IFN-??+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder, PLoS ONE, vol.79, issue.10, p.6517, 2009.
DOI : 10.1371/journal.pone.0006517.s002

Y. Yamano, N. Takenouchi, H. Li, U. Tomaru, K. Yao et al., Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I???associated neuroimmunological disease, Journal of Clinical Investigation, vol.115, issue.5, pp.1361-1368, 2005.
DOI : 10.1172/JCI23913DS1

O. Hu,-g-r-a-n-tc,-g-r-i-f-f-i-t-hc and . Ok, J a c o b s o nS :Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection, pp.1557-1566

J. Michaelsson, H. Barbosa, K. Jordan, J. Chapman, M. Brunialti et al., The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis, BMC Immunology, vol.9, issue.1, p.41, 2008.
DOI : 10.1186/1471-2172-9-41

D. Hayashi, R. Kubota, N. Takenouchi, Y. Tanaka, R. Hirano et al., Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy, Journal of Neuroimmunology, vol.200, issue.1-2, pp.115-124, 2008.
DOI : 10.1016/j.jneuroim.2008.06.005

J. Ramirez, N. Brembilla, O. Sorg, R. Chicheportiche, T. Matthes et al., Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells, European Journal of Immunology, vol.107, issue.9, pp.2450-2459, 2010.
DOI : 10.1002/eji.201040461

N. Mori, P. Gill, T. Mougdil, S. Murakami, S. Eto et al., Interleukin-10 Gene Expression and Adult T-Cell Leukemia, Leukemia & Lymphoma, vol.81, issue.3-4, pp.1035-1045, 1996.
DOI : 10.1073/pnas.92.4.1057

R. Rautert, T. Schinkothe, J. Franklin, M. Weihrauch, B. Boll et al., Elevated pretreatment interleukin-10 serum level is an International Prognostic Score (IPS)-independent risk factor for early treatment failure in advanced stage Hodgkin lymphoma, Leukemia & Lymphoma, vol.19, issue.11, pp.2091-2098, 2008.
DOI : 10.1093/annonc/mdm132

D. Fiorentino, M. Bond, and T. Mosmann, Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones, Journal of Experimental Medicine, vol.170, issue.6, pp.2081-2095, 1989.
DOI : 10.1084/jem.170.6.2081

K. Taga, H. Mostowski, and G. Tosato, Human interleukin-10 can directly inhibit T-cell growth, Blood, vol.81, pp.2964-2971, 1993.

M. Washiyama, K. Nishigaki, N. Ahmed, S. Kinpara, Y. Ishii et al., IL-2 withdrawal induces HTLV-1 expression through p38 activation in ATL cell lines, FEBS Letters, vol.12, issue.27, pp.5207-5212, 2007.
DOI : 10.1016/j.febslet.2007.10.008

S. Mitra-kaushik, J. Harding, J. Hess, R. Schreiber, and L. Ratner, Enhanced tumorigenesis in HTLV-1 Tax-transgenic mice deficient in interferon-gamma, Blood, vol.104, issue.10, pp.3305-3311, 2004.
DOI : 10.1182/blood-2004-01-0266

X. Xu, O. Heidenreich, I. Kitajima, K. Mcguire, Q. Li et al., Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis, Oncogene, vol.13, pp.135-142, 1996.

H. Yano, T. Ishida, A. Inagaki, T. Ishii, S. Kusumoto et al., Regulatory T-cell function of adult T-cell leukemia/lymphoma cells, International Journal of Cancer, vol.20, issue.9, pp.2052-2057, 2007.
DOI : 10.1002/ijc.22536

M. Li-weber, M. Giaisi, K. Chlichlia, K. Khazaie, and P. Krammer, Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells, European Journal of Immunology, vol.94, issue.9
DOI : 10.1002/1521-4141(200109)31:9<2623::AID-IMMU2623>3.0.CO;2-4

T. Portis, J. Harding, and L. Ratner, The contribution of NF-kappaB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors, Blood, vol.98, issue.4, pp.1200-1208, 2001.
DOI : 10.1182/blood.V98.4.1200

R. Nasr, E. Hajj, H. Kfoury, Y. De-thé, H. Hermine et al., Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?, Viruses, vol.3, issue.12, pp.750-769, 2011.
DOI : 10.3390/v3060750

A. Datta, M. Bellon, U. Sinha-datta, A. Bazarbachi, Y. Lepelletier et al., Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence, Blood, vol.108, issue.3, pp.1021-1029, 2006.
DOI : 10.1182/blood-2006-01-0067
URL : https://hal.archives-ouvertes.fr/hal-00022487

. Kchour, The combination of arsenic, interferon-alpha, and zidovudine restores an ???immunocompetent-like??? cytokine expression profile in patients with adult T-cell leukemia lymphoma, Retrovirology, vol.10, issue.1, p.91, 2013.
DOI : 10.1182/blood-2006-01-0067
URL : https://hal.archives-ouvertes.fr/inserm-00868737