Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles PLoS ONE Year : 2013

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and is often characterized by mutations or deletions of the Von Hippel Lindau (VHL) tumour suppressor gene. Aurora gene family members are implicated in proper mitotic progression and spindle checkpoint function and play a crucial role in cancer progression. In the present study, we assessed the expression of Aurora-A in a cohort of 30 ccRCC with fully characterized VHL status (wt/wt or mut/del) and Fuhrman grade. Aurora-A transcript and protein levels were significantly increased in high Fuhrman grade tumours and in VHLwt/wt tumours. These results suggest that Aurora-A and VHL interact in the ccRCC. We demonstrated that the two proteins interact in vivo and identified the Ser72 on the sequence of VHL as the unique site phosphorylated by Aurora-A.
Fichier principal
Vignette du fichier
PMID_23785518.pdf (2.21 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-00865341 , version 1 (24-09-2013)

Identifiers

Cite

Benedicte Martin, Franck Chesnel, Jean-Guy Delcros, Florence Jouan, Anne Couturier, et al.. Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).. PLoS ONE, 2013, 8 (6), pp.e67071. ⟨10.1371/journal.pone.0067071⟩. ⟨inserm-00865341⟩
291 View
338 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More