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The task force that rescues stalled ribosomes in bacteria.

Abstract : In bacteria, the main quality control mechanism for rescuing ribosomes that have arrested during translation is trans-translation, performed by transfer-mRNA (tmRNA) associated with small protein B (SmpB). Intriguingly, this very elegant mechanism is not always necessary to maintain cell viability, suggesting the existence of alternatives. Other rescue systems have recently been discovered, revealing a far more complicated story than expected. These include the alternative ribosome rescue factors ArfA and ArfB, the elongation factors EF4 and EF-P, the peptidyl-tRNA hydrolase Pth, and several protein synthesis factors. These discoveries make it possible to describe a large network of factors dedicated to ribosome rescue, thus ensuring cell survival during stresses that induce ribosome stalling.
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https://www.hal.inserm.fr/inserm-00865335
Contributor : Clémence Martin <>
Submitted on : Tuesday, September 24, 2013 - 12:31:05 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:52 AM

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Emmanuel Giudice, Reynald Gillet. The task force that rescues stalled ribosomes in bacteria.. Trends in Biochemical Sciences, Elsevier, 2013, 38 (8), pp.403-11. ⟨10.1016/j.tibs.2013.06.002⟩. ⟨inserm-00865335⟩

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