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Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation.

François Ferriere 1, * Denis Habauzit 1 Farzad Pakdel 1 Christian Saligaut 1 Gilles Flouriot 1 
* Corresponding author
1 Trec - Transcription, environnement et cancer
Irset - Institut de recherche en santé, environnement et travail
Abstract : Many studies have reported proliferative, differentiating or protective effects of estradiol, notably through estrogen receptor alpha (ERα). On the contrary, the ligand-independent action of ERα is currently poorly documented notably in cell protection. The stable transfection of wild type, substituted or truncated form of ERα in PC12 cells (ERα negative cell line) lead the specific study of its ligand-independent action. Hence, we demonstrate here that, in the absence of E2, the expression of ERα prevents cells from apoptosis induced by serum deprivation. This protection is not due to an ERE-mediated transcription and does not require either AF-1 or AF-2 transactivation functions. It is afforded to the Y537 residue of ERα and activation of c-Src/Stat3 signaling pathway.
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Submitted on : Tuesday, September 24, 2013 - 12:21:44 PM
Last modification on : Wednesday, March 30, 2022 - 2:35:45 PM
Long-term archiving on: : Wednesday, December 25, 2013 - 4:33:20 AM


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François Ferriere, Denis Habauzit, Farzad Pakdel, Christian Saligaut, Gilles Flouriot. Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation.. PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e69081. ⟨10.1371/journal.pone.0069081⟩. ⟨inserm-00865332⟩



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