Intrahepatic cholangiocarcinoma: impact of genetic hemochromatosis on outcome and overall survival after surgical resection.

Laurent Sulpice 1, 2, * Michel Rayar 2 Eveline Boucher 1, 3 Fabienne Pele 4 Marc Pracht 3 Bernard Meunier 2 Karim Boudjema 1
* Auteur correspondant
1 Foie, métabolismes et cancer
2 Service de Chirurgie Hépatobiliaire et Digestive
3 CRLCC - CRLCC Eugène Marquis
4 Service d'Epidémiologie
Abstract : BACKGROUND: The influence of genetic hemochromatosis (GH) on outcomes following surgical resections for intrahepatic cholangiocarcinoma (ICC) has not been evaluated. METHODS: All patients with ICC who underwent a surgical resection between January 1997 and August 2011 were analyzed retrospectively. Risk factors were assessed by univariate and multivariate analyses. RESULTS: Eighty-seven patients were analyzed; 16 of these patients (18.4%) had GH. Among the 71 non-GH patients, 52 (73.2%) and 19 (26.8%) had normal or cirrhotic parenchyma, respectively. There was no significant difference in survival between the GH and non-GH patients. A univariate analysis showed that major hepatectomy (P = 0.012), intraoperative blood transfusion (P = 0.007), tumor size >5 cm (P = 0.006), several nodules (P < 0.001), and microvascular invasion (P = 0.04) were significantly associated with poor survival. A multivariate analysis showed that intraoperative blood infusion (HR 0.37; CI 95% [0.19; 0.71]) and more than one nodule (HR 2.5; CI 95% [1.06; 5.8]) were associated with a lower survival rate. CONCLUSION: Although the incidence of GH was high in our series, the presence of GH did not affect the outcomes after a liver hepatectomy for ICC. GH does not appear to increase recurrences or worsen the overall and disease-free survival.
Keywords : Intrahepatic cholangiocarcinoma Genetic hemochromatosis Overall survival
Type de document :
Article dans une revue
Journal of Surgical Research, Elsevier, 2013, 180 (1), pp.56-61. 〈10.1016/j.jss.2012.10.051〉
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http://www.hal.inserm.fr/inserm-00865277
Contributeur : Morgane Le Corre <>
Soumis le : mardi 24 septembre 2013 - 11:19:10
Dernière modification le : mercredi 16 mai 2018 - 11:24:07

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FNCLCC | MARQUIS | BIOSIT | NUMECAN | NUMECAN-TGTC | UR1-UFR-SVE | UNIV-RENNES

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Laurent Sulpice, Michel Rayar, Eveline Boucher, Fabienne Pele, Marc Pracht, et al.. Intrahepatic cholangiocarcinoma: impact of genetic hemochromatosis on outcome and overall survival after surgical resection.. Journal of Surgical Research, Elsevier, 2013, 180 (1), pp.56-61. 〈10.1016/j.jss.2012.10.051〉. 〈inserm-00865277〉

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