 |
Journal articles
Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.
Abstract : New N,N'-bis(5-arylidene-4-oxo-4,5-dihydrothiazoline-2-yl)diamine derivatives 5 were prepared in two steps from rhodanine and piperazine, or 1,4-bis(3-amino-propyl)piperazine, under microwave reaction conditions with retention of configuration. Some of these compounds were tested for in vitro antiproliferative activities and for their kinase inhibitory potencies towards six kinases (CDK5/p25, GSK3α/β, DYRK1A, DYRK2, CLK1, and CLK2). The compound 5d showed nanomolar activity towards DYRK1A kinase (IC(50) = 0.041 μM).
Cited literature [12 references]
https://www.hal.inserm.fr/inserm-00864810
Contributor : Morgane Le Corre <>
Submitted on : Monday, September 23, 2013 - 12:03:25 PM
Last modification on : Wednesday, April 7, 2021 - 3:18:05 PM
Long-term archiving on: : Friday, April 7, 2017 - 1:34:28 AM
Contributor : Morgane Le Corre <>
Submitted on : Monday, September 23, 2013 - 12:03:25 PM
Last modification on : Wednesday, April 7, 2021 - 3:18:05 PM
Long-term archiving on: : Friday, April 7, 2017 - 1:34:28 AM
File
scipharm-2012-80-825.pdf
Publisher files allowed on an open archive