Regulation of signal transduction by glutathione transferases. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles International Journal of Hepatology Year : 2012

Regulation of signal transduction by glutathione transferases.


Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents. However, this protein family is also involved in the metabolism of endogenous compounds which play critical roles in the regulation of signaling pathways. For example, the lipid peroxidation product 4-hydroxynonenal (4-HNE) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin J(2) (15d-PGJ(2)) are metabolized by GSTs and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis. Furthermore, several studies have demonstrated that GSTs are able to interact with different protein partners such as mitogen activated protein kinases (i.e., c-jun N-terminal kinase (JNK) and apoptosis signal-regulating kinase 1 (ASK1)) which are also involved in cell signaling. New functions of GSTs, including S-glutathionylation of proteins by GSTs and ability to be a nitric oxide (NO) carrier have also been described. Taken together, these observations strongly suggest that GST might play a crucial role during normal or cancer cells proliferation or apoptosis.
Fichier principal
Vignette du fichier
137676.pdf (1.29 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-00864682 , version 1 (23-09-2013)



Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Aninat. Regulation of signal transduction by glutathione transferases.. International Journal of Hepatology, 2012, 2012, pp.137676. ⟨10.1155/2012/137676⟩. ⟨inserm-00864682⟩
278 View
366 Download



Gmail Facebook Twitter LinkedIn More