Regulation of signal transduction by glutathione transferases.

Abstract : Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents. However, this protein family is also involved in the metabolism of endogenous compounds which play critical roles in the regulation of signaling pathways. For example, the lipid peroxidation product 4-hydroxynonenal (4-HNE) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin J(2) (15d-PGJ(2)) are metabolized by GSTs and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis. Furthermore, several studies have demonstrated that GSTs are able to interact with different protein partners such as mitogen activated protein kinases (i.e., c-jun N-terminal kinase (JNK) and apoptosis signal-regulating kinase 1 (ASK1)) which are also involved in cell signaling. New functions of GSTs, including S-glutathionylation of proteins by GSTs and ability to be a nitric oxide (NO) carrier have also been described. Taken together, these observations strongly suggest that GST might play a crucial role during normal or cancer cells proliferation or apoptosis.
Type de document :
Article dans une revue
International Journal of Hepatology, 2012, 2012, pp.137676. 〈10.1155/2012/137676〉
Liste complète des métadonnées

Littérature citée [76 références]  Voir  Masquer  Télécharger
Contributeur : Morgane Le Corre <>
Soumis le : lundi 23 septembre 2013 - 09:44:24
Dernière modification le : mercredi 16 mai 2018 - 11:23:30


Fichiers éditeurs autorisés sur une archive ouverte



Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Aninat. Regulation of signal transduction by glutathione transferases.. International Journal of Hepatology, 2012, 2012, pp.137676. 〈10.1155/2012/137676〉. 〈inserm-00864682〉



Consultations de la notice


Téléchargements de fichiers