Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.
(1)
,
(2)
,
(3)
,
(4)
,
(5)
,
(6)
,
(7)
,
(8)
,
(9)
,
(10)
,
(11)
,
(9)
,
(3)
,
(1)
,
(12)
,
(4)
,
(13)
,
(8)
,
(14)
,
(7)
,
(4, 15)
,
(16)
,
(3)
,
(17)
,
(18)
,
(6)
,
(11)
,
(19)
,
(20)
,
(1)
,
(16)
,
(21, 22)
,
(23)
,
(24)
,
(14)
,
(23)
,
(25, 26)
,
(3)
,
(17)
,
(27)
,
(3)
,
(28)
,
(25, 26)
,
(29)
,
(30)
,
(31)
,
(32, 28)
,
(3)
,
(33, 34)
,
(17)
,
(25, 35, 36)
,
(37)
,
(38)
,
(5)
,
(6)
,
(32)
,
(39)
,
(16)
,
(38)
,
(5)
,
(29)
,
(40)
,
(1)
,
(33, 34)
,
(41, 42)
,
(43)
,
(44)
,
(16, 45)
,
(23)
,
(29)
,
(10)
,
(3)
,
(46, 47)
,
(30)
,
(33, 34)
,
(19)
,
(8)
,
(16)
,
(18)
,
(48)
,
(15)
,
(11)
,
(1)
,
(43)
,
(15)
,
(2)
,
(3)
,
(40)
,
(16)
,
(38)
,
(49)
,
(50)
,
(39)
,
(51)
,
(23)
,
(44)
,
(52)
,
(3)
,
(3, 16, 23, 52)
,
(1)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Frank Bellivier
- Function : Author
- PersonId : 757742
- ORCID : 0000-0002-3660-6640
- IdRef : 070265062
Scott Clark
- Function : Author
- PersonId : 769345
- ORCID : 0000-0003-1640-5611
Bruno Etain
- Function : Author
- PersonId : 757741
- IdHAL : bruno-etain
- ORCID : 0000-0002-5377-1488
- IdRef : 074181106
Julie Garnham
- Function : Author
- PersonId : 769346
- ORCID : 0000-0002-7987-4995
Joanna Hauser
- Function : Author
- PersonId : 765438
- ORCID : 0000-0002-6621-3493
Urs Heilbronner
- Function : Author
- PersonId : 769347
- ORCID : 0000-0001-7135-762X
Stéphane Jamain
- Function : Author
- PersonId : 745408
- IdHAL : stephane-jamain
- ORCID : 0000-0002-4321-4100
- IdRef : 07777146X
Ichiro Kusumi
- Function : Author
- PersonId : 769349
- ORCID : 0000-0002-8747-5070
Catharina Lavebratt
- Function : Author
- PersonId : 769121
- ORCID : 0000-0003-4987-2718
Marion Leboyer
- Function : Author
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Urban Osby
- Function : Author
Norio Ozaki
- Function : Author
- PersonId : 769350
- ORCID : 0000-0002-7360-4898
Andreas Reif
- Function : Author
- PersonId : 763135
- ORCID : 0000-0002-0992-634X
Maria Grigoroiu-Serbanescu
- Function : Author
- PersonId : 769351
- ORCID : 0000-0002-1304-6687
Giovanni Severino
- Function : Author
- PersonId : 769352
- ORCID : 0000-0002-6354-2662
Alessio Squassina
- Function : Author
- PersonId : 769353
- ORCID : 0000-0001-7415-7607
Gustavo Turecki
- Function : Author
- PersonId : 769354
- ORCID : 0000-0003-4075-2736
Michael Bauer
- Function : Author
- PersonId : 765030
- ORCID : 0000-0002-2666-859X
Marcella Rietschel
- Function : Author
- PersonId : 757743
- ORCID : 0000-0002-5236-6149
Martin Alda
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 945734
Connectez-vous pour contacter l'auteur
Abstract
OBJECTIVE: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. MATERIALS AND METHODS: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. RESULTS: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). CONCLUSIONS: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.
Origin : Publisher files allowed on an open archive
Loading...