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The HLA-G low expressor genotype is associated with protection against bipolar disorder.

Abstract : Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
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Submitted on : Monday, September 23, 2013 - 8:25:52 AM
Last modification on : Monday, March 14, 2022 - 4:52:06 PM
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Monojit Debnath, Marc Busson, Stéphane Jamain, Bruno Etain, Nora Hamdani, et al.. The HLA-G low expressor genotype is associated with protection against bipolar disorder.. Human Immunology, Elsevier, 2013, 74 (5), pp.593-7. ⟨10.1016/j.humimm.2012.11.032⟩. ⟨inserm-00864639⟩



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