The HLA-G low expressor genotype is associated with protection against bipolar disorder.

Monojit Debnath; Marc Busson; Stéphane Jamain; Bruno Etain; Nora Hamdani; Hélène Moins-Teisserenc; Wahid Boukouaci; Mohamed Lajnef; Djaouida Bengoufa; Alain Malafosse; Frank Bellivier; Chantal Henry; Jean-Pierre Kahn; Rajagopal Krishnamoorthy; Dominique Charron; Marion Leboyer; Ryad Tamouza

doi:10.1016/j.humimm.2012.11.032

Journal articles

The HLA-G low expressor genotype is associated with protection against bipolar disorder.

Monojit Debnath ^{1, 2} Marc Busson ^{3, 1} Stéphane Jamain ^{2, 4, 5, 6} Bruno Etain ^{2, 4, 5, 6} Nora Hamdani ^{2, 4, 5, 6} Hélène Moins-Teisserenc ^{1, 3, 6} Wahid Boukouaci ^{1, 3} Mohamed Lajnef ^{2, 4, 5, 6} Djaouida Bengoufa ³ Alain Malafosse ⁷ Frank Bellivier ^{2, 4, 5, 6} Chantal Henry ^{2, 4, 5, 6} Jean-Pierre Kahn ⁸ Rajagopal Krishnamoorthy ^{1, 6, 9} Dominique Charron ^{1, 3, 6} Marion Leboyer ^{2, 4, 5, 6} Ryad Tamouza ^{1, 3, 6, *}

* Corresponding author

1 Hématologie -Immunologie -Cibles thérapeutiques

2 IMRB - Institut Mondor de Recherche Biomédicale

3 Laboratoire Jean Dausset

4 Service de Psychiatrie

5 Pôle de Psychiatrie [Créteil]

6 Fondation FondaMental [Créteil]

7 Département de Psychiatrie

8 Service de Psychiatrie et Psychologie Clinique

9 Pharmacogénétique et abords thérapeutiques des maladies héréditaires

Abstract : Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.

Keywords : Bipolar disorders HLA-G Polymorphism Immune modulation Seasonality of birth

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Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

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