Skip to Main content Skip to Navigation
Journal articles

Clinical review: The liver in sepsis.

Abstract : ABSTRACT: During sepsis, the liver plays a key role. It is implicated in the host response, participating in the clearance of the infectious agents/products. Sepsis also induces liver damage through hemodynamic alterations or through direct or indirect assault on the hepatocytes or through both. Accordingly, liver dysfunction induced by sepsis is recognized as one of the components that contribute to the severity of the disease. Nevertheless, the incidence of liver dysfunction remains imprecise, probably because current diagnostic tools are lacking, notably those that can detect the early liver insult. In this review, we discuss the epidemiology, diagnostic tools, and impact on outcome as well as the pathophysiological aspects, including the cellular events and clinical picture leading to liver dysfunction. Finally, therapeutic considerations with regard to the weakness of the pertinent specific approach are examined.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00864250
Contributor : Morgane Le Corre <>
Submitted on : Friday, September 20, 2013 - 4:06:58 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:30 AM

Links full text

Identifiers

Citation

Nicolas Nesseler, Yoann Launey, Caroline Aninat, Fabrice Morel, Yannick Mallédant, et al.. Clinical review: The liver in sepsis.. Critical Care, BioMed Central, 2012, 16 (5), pp.235. ⟨10.1186/cc11381⟩. ⟨inserm-00864250⟩

Share

Metrics

Record views

228