Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways. - Archive ouverte HAL Access content directly
Journal Articles Int J Endocrinol Year : 2013

Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways.

(1) , (1) , (1)
1

Abstract

In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel of in vivo and in vitro bioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens.
Fichier principal
Vignette du fichier
501851.pdf (2.21 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-00863365 , version 1 (19-09-2013)

Identifiers

Cite

Gwenneg Kerdivel, Denis Habauzit, Farzad Pakdel. Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways.. Int J Endocrinol, 2013, 2013, pp.501851. ⟨10.1155/2013/501851⟩. ⟨inserm-00863365⟩
245 View
391 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More